Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation.
Anel Lizcano,Ismael Secundino,Simon Döhrmann,Ross Corriden,Cristina C. Rohena,Sandra Diaz,Pradipta Ghosh,Lingquan Deng,Victor Nizet,Ajit Varki +9 more
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TLDR
It is proposed that a sialic acid-based "self-associated molecular pattern" on erythrocytes also helps maintain neutrophil quiescence in the bloodstream and help explain why neutrophils become easily activated after separation from whole blood.About:
This article is published in Blood.The article was published on 2017-06-08 and is currently open access. It has received 61 citations till now. The article focuses on the topics: Neutrophil extracellular traps & Cell activation.read more
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Journal ArticleDOI
Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins
TL;DR: The presence of Siglec in different classes of vertebrates is focused on, offering a bridge between the presence of different Siglecs and the biological situations of the selected animals, to reveal the conservation of SigLecs throughout evolution.
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Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses
Heinz Läubli,Ajit Varki +1 more
TL;DR: Experimental evidence for the role of Siglecs—in particular CD33-related Siglec—as self-receptors and their sialoglycan ligands in regulating this balance between recognition of self and non-self is summarized.
Journal ArticleDOI
Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment.
Kelly L. Singel,Tiffany R. Emmons,Anm Nazmul H. Khan,P.C. Mayor,Shichen Shen,Jerry T. Wong,Kayla Morrell,Kevin H. Eng,Jaron Mark,Richard B. Bankert,Junko Matsuzaki,Richard C. Koya,Anna M. Blom,Kenneth R. McLeish,Jun Qu,Sanjay Ram,Kirsten B. Moysich,Scott I. Abrams,Kunle Odunsi,Emese Zsiros,Brahm H. Segal +20 more
TL;DR: Inhibition of complement C3 activation and PMN effector functions, including CR3 signaling, protein synthesis, and vesicular trafficking, abrogated the PMN suppressor phenotype.
Journal ArticleDOI
Probing the binding specificities of human Siglecs by cell-based glycan arrays
Christian Büll,Rebecca Nason,Lingbo Sun,Julie Van Coillie,Daniel Madriz Sørensen,Sam J. Moons,Zhang Yang,Steven Arbitman,Steve M. Fernandes,Sanae Furukawa,Ryan McBride,Corwin M. Nycholat,Gosse J. Adema,James C. Paulson,Ronald L. Schnaar,Thomas J. Boltje,Henrik Clausen,Yoshiki Narimatsu +17 more
TL;DR: Siglec-4/7/15 all have distinct binding preferences for sialylated GalNAc-type O-glycans but exhibit selectivity for patterns of O- glycans as presented on distinct protein sequences.
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Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing
Satoshi Uchiyama,Josh Sun,Kyoko Fukahori,Nao Ando,Mengyou Wu,Flavio Schwarz,Shoib S. Siddiqui,Shoib S. Siddiqui,Ajit Varki,Jamey D. Marth,Jamey D. Marth,Victor Nizet +11 more
TL;DR: GBS Sia has dual roles in counteracting platelet antimicrobial immunity: conferring intrinsic resistance to platelet-derived antimicrobial components and inhibiting platelet activation through engagement of inhibitory Siglecs.
References
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Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
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Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
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Neutrophils in the activation and regulation of innate and adaptive immunity
TL;DR: Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens, but more recent evidence has extended the functions of these cells.
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Neutrophil Function: From Mechanisms to Disease
TL;DR: A survey of basic neutrophil biology, with an emphasis on examples that highlight the function of neutrophils not only as professional killers, but also as instructors of the immune system in the context of infection and inflammatory disease.
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Neutrophil kinetics in health and disease
Charlotte Summers,Sara M. Rankin,Alison M. Condliffe,Nanak R. Singh,A. Michael Peters,Edwin R. Chilvers +5 more
TL;DR: Current understanding of how neutrophils are released from the bone marrow is outlined, in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis and the relative size and role of freely circulating and marginated pools within the vascular compartment are outlined.