C
Cristina Ivan
Researcher at University of Texas MD Anderson Cancer Center
Publications - 197
Citations - 12070
Cristina Ivan is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 51, co-authored 182 publications receiving 9540 citations. Previous affiliations of Cristina Ivan include University of Texas Health Science Center at Houston & Leibniz University of Hanover.
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Journal ArticleDOI
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
Sonia A. Melo,Hikaru Sugimoto,Hikaru Sugimoto,Joyce T. O’Connell,Noritoshi Kato,Alberto Villanueva,August Vidal,Le Qiu,Edward Vitkin,Lev T. Perelman,Carlos A. Melo,Anthony Lucci,Cristina Ivan,George A. Calin,Raghu Kalluri,Raghu Kalluri +15 more
TL;DR: It is reported that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor micro RNAs (pre-miRNas) into mature miRNAs.
Journal ArticleDOI
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
Hui Ling,Riccardo Spizzo,Yaser Atlasi,Milena S. Nicoloso,Masayoshi Shimizu,Roxana S. Redis,Roxana S. Redis,Naohiro Nishida,Naohiro Nishida,Roberta Gafà,Jian Song,Zhiyi Guo,Cristina Ivan,Elisa Barbarotto,Ingrid de Vries,Xinna Zhang,Manuela Ferracin,Mike Churchman,Janneke F. van Galen,Berna Beverloo,Maryam Shariati,Franziska Haderk,Franziska Haderk,Marcos R. Estecio,Guillermo Garcia-Manero,Gijs A. Patijn,David C. Gotley,Vikas Bhardwaj,Imad Shureiqi,Subrata Sen,Asha S. Multani,James W. Welsh,Ken Yamamoto,Itsuki Taniguchi,Min-Ae Song,Steven Gallinger,Graham Casey,Stephen N. Thibodeau,Loic Le Marchand,Maarit Tiirikainen,Sendurai A. Mani,Wei Zhang,Ramana V. Davuluri,Koshi Mimori,Masaki Mori,Anieta M. Sieuwerts,John W.M. Martens,Ian Tomlinson,Massimo Negrini,Ioana Berindan-Neagoe,John A. Foekens,Stanley R. Hamilton,Giovanni Lanza,Scott Kopetz,Riccardo Fodde,George A. Calin +55 more
TL;DR: The results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk.
Journal ArticleDOI
PDL1 Regulation by p53 via miR-34
Maria Angelica Cortez,Cristina Ivan,David Valdecanas,Xiaohong Wang,Heidi J. Peltier,Yuping Ye,Luiz H. Araujo,David P. Carbone,Konstantin Shilo,Dipak Giri,Kevin Kelnar,Desiree Martin,Ritsuko Komaki,Daniel R. Gomez,Sunil Krishnan,George A. Calin,Andreas G. Bader,James W. Welsh +17 more
TL;DR: The results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer, and identify a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis.
Journal ArticleDOI
PD-L1 expression and prognostic impact in glioblastoma.
Edjah K. Nduom,Jun Wei,Nasser K. Yaghi,Neal Huang,Ling Yuan Kong,Konrad Gabrusiewicz,Xiaoyang Ling,Shouhao Zhou,Cristina Ivan,Jie Qing Chen,Jared K. Burks,Gregory N. Fuller,George A. Calin,Charles A. Conrad,Caitlin Creasy,Krit Ritthipichai,Laszlo Radvanyi,Amy B. Heimberger +17 more
TL;DR: The incidence of PD-L1 expression in GBM patients is frequent but is confined to a minority subpopulation, similar to other malignancies that have been profiled for PD- L1 expression.
Journal ArticleDOI
Tumour angiogenesis regulation by the miR-200 family
Chad V. Pecot,Rajesha Rupaimoole,Da Yang,Rehan Akbani,Cristina Ivan,Chunhua Lu,Sherry Y. Wu,Hee Dong Han,Maitri Y. Shah,Cristian Rodriguez-Aguayo,Justin Bottsford-Miller,Yuexin Liu,Sang Bae Kim,Anna K. Unruh,Vianey Gonzalez-Villasana,Huang L,Behrouz Zand,Myrthala Moreno-Smith,Lingegowda S. Mangala,Morgan Taylor,Heather J. Dalton,Vasudha Sehgal,Yunfei Wen,Yu Kang,Keith A. Baggerly,Ju Seog Lee,Prahlad T. Ram,Murali Ravoori,Vikas Kundra,Xinna Zhang,Rouba Ali-Fehmi,Ana M. Gonzalez-Angulo,Pierre P. Massion,George A. Calin,Gabriel Lopez-Berestein,Wei Zhang,Anil K. Sood +36 more
TL;DR: A difference in clinical outcome is demonstrated based on miR-200's role in blocking tumour angiogenesis, defined as its utility as a potential therapeutic agent in a cancer-dependent context.