D
Dan Lindholm
Researcher at Minerva Foundation Institute for Medical Research
Publications - 266
Citations - 25963
Dan Lindholm is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Nerve growth factor & Neurotrophic factors. The author has an hindex of 70, co-authored 235 publications receiving 23924 citations. Previous affiliations of Dan Lindholm include University of Melbourne & Max Planck Society.
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Destabilization of the outer and inner mitochondrial membranes by core and linker histones.
TL;DR: It is concluded that histones destabilize the mitochondrial membranes, a mechanism that may convey genotoxic signals to mitochondria and promote apoptosis following DNA damage.
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PGC-1α: a master gene that is hard to master
TL;DR: It is shown that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons, and can these seemingly conflicting findings tell us something about the role of P GC-1 α in cell stress and in control of neuronal homeostasis.
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Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth
Hai Thi Do,Hai Thi Do,Céline Bruelle,Céline Bruelle,Dan Duc Pham,Dan Duc Pham,Matti Jauhiainen,Ove Eriksson,Laura Korhonen,Laura Korhonen,Laura Korhonen,Dan Lindholm,Dan Lindholm +12 more
TL;DR: It is shown that NGF and simvastatin are able to stimulate lipoprotein uptake by neurons with a positive effect on neurite outgrowth and increases in LDLRs and lipop protein particles in neurons could play a functional role during brain development, in neuroregeneration and after brain injuries.
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BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways.
TL;DR: The results suggest that the neuroprotective effect of BDNF requires activation of both phosphatidylinositol-3 kinase and the Ras/MAP kinase cascade and that CNTF signaling through other pathways is without an effect in this system.
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MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain
Beat Bornhauser,Dan Lindholm +1 more
TL;DR: It is shown that MRLC-interacting protein (MIR)-interacting saposin-like protein (MSAP) enhances cell spreading in fibroblasts and migration of rat C6 glioma cells through increases in MRLC phosphorylation, which is independent of the activity of MRLC kinase.