D
Dan Lindholm
Researcher at Minerva Foundation Institute for Medical Research
Publications - 266
Citations - 25963
Dan Lindholm is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Nerve growth factor & Neurotrophic factors. The author has an hindex of 70, co-authored 235 publications receiving 23924 citations. Previous affiliations of Dan Lindholm include University of Melbourne & Max Planck Society.
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Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus.
TL;DR: The reciprocal regulation of ACh, NGF and BDNF in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity.
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Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain--implications for neuronal plasticity.
TL;DR: The rapid regulation of NGF and BDNF by subtle physiological stimuli together with the recent demonstration that the neurotrophin release neurotransmitters such as acetylcholine opens up interesting perspectives for the function of neurotrophins as mediators of neuronal plasticity.
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Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain
Anna-Leena Sokka,Noora Putkonen,Giuseppa Mudò,Evgeny Pryazhnikov,Sami Reijonen,Leonard Khiroug,Natale Belluardo,Dan Lindholm,Laura Korhonen +8 more
TL;DR: Salubrinal, inhibiting eIF2α (eukaryotic translation initiation factor 2 subunit α) dephosphorylation, significantly reduced KA-induced ER stress and neuronal death in vivo and in vitro and show that ER responses are essential parts of excitotoxicity mediated by glutamate receptor activation.
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Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity.
TL;DR: BDNF, but not NT‐3, is a survival factor for cultured cerebellar granule neurons and activation of glutamate receptor(s) up‐regulates BDNF expression in these cells.
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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
Giuseppa Mudò,Johanna Mäkelä,Valentina Di Liberto,Timofey V. Tselykh,Melania Olivieri,Petteri Piepponen,Ove Eriksson,Annika Mälkiä,Alessandra Bonomo,Minna Kairisalo,Jose A. Aguirre,Laura Korhonen,Natale Belluardo,Dan Lindholm +13 more
TL;DR: It is shown here that transgenic mice overexpressing PGC-1 α in dopaminergic neurons are resistant against cell degeneration induced by the neurotoxin MPTP, and RSV and other compounds acting via SIRT1/PGC-1α may prove useful as neuroprotective agents in PD and possibly in other neurological disorders.