D
Dan Lindholm
Researcher at Minerva Foundation Institute for Medical Research
Publications - 266
Citations - 25963
Dan Lindholm is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Nerve growth factor & Neurotrophic factors. The author has an hindex of 70, co-authored 235 publications receiving 23924 citations. Previous affiliations of Dan Lindholm include University of Melbourne & Max Planck Society.
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Journal ArticleDOI
Paradoxical increase in neuronal DNA fragmentation after neuroprotective free radical scavenger treatment in experimental traumatic brain injury
Anders Lewén,Ylva Skoglösa,Fredrik Clausen,Niklas Marklund,Pak H. Chan,Dan Lindholm,Lars Hillered +6 more
TL;DR: It is concluded that a treatment producing an increase in DNA fragmentation in the early phase may be compatible with an overall beneficial effect on outcome after TBI and should be considered in the screening process for future neuroprotective remedies.
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Early diagnosis of acute coronary syndrome
Hugo A. Katus,André Ziegler,Okan Ekinci,Okan Ekinci,Evangelos Giannitsis,Wendy Gattis Stough,Stephan Achenbach,Stefan Blankenberg,Martina Brueckmann,Martina Brueckmann,Paul O. Collinson,Paul O. Collinson,Dorin Comaniciu,Filippo Crea,Wilfried Dinh,Gregory Ducrocq,Frank A. Flachskampf,Keith A.A. Fox,Matthias G Friedrich,Matthias G Friedrich,Kathy Hebert,Anders Himmelmann,Mark A. Hlatky,Dominik Lautsch,Bertil Lindahl,Dan Lindholm,Nicholas L. Mills,Giorgio Minotti,Martin Möckel,Torbjørn Omland,Veronique Semjonow +30 more
TL;DR: In this article, the authors proposed approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome.
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Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death
Sami Reijonen,Jyrki P. Kukkonen,Alise Hyrskyluoto,Jenny Kivinen,Minna Kairisalo,Nobuyuki Takei,Dan Lindholm,Laura Korhonen +7 more
TL;DR: The results show that calpastatin and an altered NF-κB-p65 signaling are crucial factors involved in oxidative stress and cell death mediated by mutant huntingtin proteins.
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Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells.
Minna Kairisalo,Alessandra Bonomo,Alessandra Bonomo,Alise Hyrskyluoto,Giuseppa Mudò,Natale Belluardo,Laura Korhonen,Dan Lindholm,Dan Lindholm +8 more
TL;DR: It is shown that RSV reduces oxidative stress and enhances cell survival in PC6.3 cells depending on the concentration and regulates oxidative Stress and mitochondrial antioxidants in neuronal cells, which may contribute to cell protection in various brain disorders.
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Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome
Åsa Johansson,Niclas Eriksson,Dan Lindholm,Christoph Varenhorst,Stefan James,Ann-Christine Syvänen,Tomas Axelsson,Agneta Siegbahn,Bryan J. Barratt,Richard C. Becker,Anders Himmelmann,Hugo A. Katus,Philippe Gabriel Steg,Robert F. Storey,Lars Wallentin +14 more
TL;DR: Only the SLC39A8 variant, but not the NPPB variant, was associated with a clinical endpoint, and these results do not suggest that NT-proBNP levels have a direct effect on mortality in ACS patients.