D
Dan Lindholm
Researcher at Minerva Foundation Institute for Medical Research
Publications - 266
Citations - 25963
Dan Lindholm is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Nerve growth factor & Neurotrophic factors. The author has an hindex of 70, co-authored 235 publications receiving 23924 citations. Previous affiliations of Dan Lindholm include University of Melbourne & Max Planck Society.
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Journal ArticleDOI
Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy
Vignesh Srinivasan,Céline Bruelle,Enzo Scifo,Dan Duc Pham,Rabah Soliymani,Maciej Lalowski,Dan Lindholm +6 more
TL;DR: Modulation of the USP14-HSC70 axis may represent a potential therapeutic target in HD to beneficially influence multiple proteostasis pathways.
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Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein.
Johanna Mäkelä,Giuseppa Mudò,Dan Duc Pham,Valentina Di Liberto,Ove Eriksson,Lauri M. Louhivuori,Céline Bruelle,Rabah Soliymani,Marc Baumann,Laura Korhonen,Laura Korhonen,Maciej Lalowski,Natale Belluardo,Dan Lindholm +13 more
TL;DR: Results show that PGC‐1α overexpression contributes to enhanced neuronal viability by stimulating mitochondria number and respiration and increasing levels of OXPHOS proteins and the anti‐apoptotic protein XIAP.
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p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3
Dan Duc Pham,Hai Thi Do,Hai Thi Do,Céline Bruelle,Céline Bruelle,Jyrki P. Kukkonen,Ove Eriksson,Isabel Mogollón,Isabel Mogollón,Laura Korhonen,Laura Korhonen,Urmas Arumäe,Dan Lindholm +12 more
TL;DR: A novel signaling pathway triggered by ligand-activated p75NTR that via p38 MAPK and caspase-3 mediate the activation of SREBP2 is identified, which may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF and pro-NGF.
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Bcl-2 Regulates the Levels of the Cysteine Proteases ICH and CPP32/Yama in Human Neuronal Precursor Cells
TL;DR: It is shown, using the human NT‐2 neuronal cell line, that overexpression of Bcl‐2 leads to dramatic down‐regulation of the cysteine proteases ICH and CPP32/Yama, which are directly involved in cell death.
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Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction
Jawad H. Butt,Pooja Dewan,Béla Merkely,Jan Bělohlávek,Jarosław Drożdż,Masafumi Kitakaze,Silvio E. Inzucchi,Mikhail Kosiborod,Felipe Martinez,Sergey Tereshchenko,Piotr Ponikowski,Olof Bengtsson,Dan Lindholm,Anna Maria Langkilde,Morten Schou,Mikaela Sjöstrand,Scott D. Solomon,Marc S. Sabatine,Chern-En Chiang,Kieran F. Docherty,Pardeep S. Jhund,Lars Køber,John J.V. McMurray +22 more
TL;DR: Dapagliflozin improved all outcomes examined, regardless of frailty status, but the absolute reductions were generally larger in the most frail patients.