D
Dan Lindholm
Researcher at Minerva Foundation Institute for Medical Research
Publications - 266
Citations - 25963
Dan Lindholm is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Nerve growth factor & Neurotrophic factors. The author has an hindex of 70, co-authored 235 publications receiving 23924 citations. Previous affiliations of Dan Lindholm include University of Melbourne & Max Planck Society.
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Journal ArticleDOI
Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin-1 and Various Growth Factors in Astrocyte Cultures and in vivo.
Matthias Spranger,Dan Lindholm,Christine E. Bandtlow,Rolf Heumann,Hannes Gnahn,Martina Näher-Noé,Hans Thoenen +6 more
TL;DR: The understanding of the physiological regulation of NGF synthesis in the CNS is the basis for a rational approach to its pharmacological modification and is an attractive alternative to the (long‐term) infusion ofNGF or the transplantation of N GF‐secreting cells with the goal of providing trophic support to the cholinergic neurons of the basal forebrain nuclei.
Journal ArticleDOI
Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus
TL;DR: In situ hybridization experiments suggest the neuroprotective action of brain-derived neurotrophic factor to be mediated via trkB – receptors in the hippocampus and a therapeutic potential for the treatment of cerebral ischemia.
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Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.
TL;DR: Evidence for a causal relationship between c-fos induction and the subsequent increase in NGF mRNA was obtained in cotransfection experiments and DNase I footprint experiments demonstrated that a binding site for transcription factor AP-1 (Fos/Jun heterodimer) in the first intron of the NGF gene was protected following c- fos induction.
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Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
Scott D. Solomon,John J.V. McMurray,Brian Claggett,W. De Boer,David L. DeMets,Adrian F. Hernandez,Silvio E. Inzucchi,Mikhail Kosiborod,Carolyn S.P. Lam,Felipe Martinez,Akshay S. Desai,Pardeep S. Jhund,Jan Bělohlávek,Chern-En Chiang,C. Jan Willem Borleffs,Josep Comín-Colet,Dan Dobreanu,Jarosław Drożdż,James C. Fang,Marco Antonio Alcocer-Gamba,Waleed Al Habeeb,Yaling Han,Jose Walter Cabrera Honorio,Stefan Janssens,Tzvetana Katova,Masafumi Kitakaze,Béla Merkely,Eileen O'Meara,José Francisco Kerr Saraiva,S. N. Tereshchenko,Jorge Thierer,Muthiah Vaduganathan,Orly Vardeny,Subodh Verma,Vinh N. Pham,Ulrica Wilderäng,Natalia Zaozerska,Erasmus Bachus,Dan Lindholm,Magnus Petersson,Anna Maria Langkilde +40 more
TL;DR: Dapagliflozin reduced the combined risk of worsening heart failure or cardiovascular death among patients with heart failure and a mildly reduced or preserved ejection fraction and results were similar in prespecified subgroups, including patients with or without diabetes.
Journal ArticleDOI
The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus.
Eero Castrén,Mervi Pitkänen,Jouni Sirviö,Alexander Parsadanian,Dan Lindholm,Hans Thoenen,P. J. Riekkinen +6 more
TL;DR: The results suggest that individual neurotrophic factors may play different roles in neuronal plasticity.