Daniel T. Shaughnessy

TL;DR: A strong correlation is observed between cellular sensitivity to MMS and the ability of cells to repair MMS-induced damage and PARP inhibition demonstrating that PARP-mediated poly(ADP-ribosyl)ation plays a role in modulation of cytotoxicity beyond recruitment of XRCC1 to sites of DNA damage.

TL;DR: This work investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function.

TL;DR: Why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and how to transition exposure research toward exposomic approaches are described.

TL;DR: There is a need for continued emphasis on studies of the interplay between genetic and environmental factors in disease and that studies need to be designed around a multifaceted approach to reflect differences in diseases, exposure attributes, and pertinent stages of human development.

TL;DR: The National Cancer Institute sponsored a "Gene-Environment Think Tank" on January 10-11, 2012 to facilitate discussions on the state of the science, the goals of G × E interaction studies in cancer epidemiology, and opportunities for developing novel study designs and analysis tools as mentioned in this paper.