D
Darius Moradpour
Researcher at University of Lausanne
Publications - 304
Citations - 23849
Darius Moradpour is an academic researcher from University of Lausanne. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 72, co-authored 287 publications receiving 22406 citations. Previous affiliations of Darius Moradpour include University of Freiburg & University Hospital of Lausanne.
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Journal ArticleDOI
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Etienne Meylan,Joseph Curran,Kay Hofmann,Darius Moradpour,Marco Binder,Ralf Bartenschlager,Jürg Tschopp +6 more
TL;DR: Cardif is described, a new CARD-containing adaptor protein that interacts with RIG-I and recruits IKKα, IKKβ and IKKɛ kinases by means of its C-terminal region, leading to the activation of NF-κB and IRF3.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Management of chronic hepatitis B
C.P.G.P.P. Marcellin,G.M. Dusheiko,Fabien Zoulim,Rafael Esteban,Stephanos J. Hadziyannis,Pietro Lampertico,M.P. Manns,Daniel Shouval,Cihan Yurdaydin,R.A. Craxi,Xavier Forns,Darius Moradpour,Jean-Michel Pawlotsky,Jörg Petersen,H.W.F. Easl +14 more
TL;DR: The objective of these EASL Clinical Practice Guidelines is to update recommendations for the optimal management of chronic hepatitis B (CHB) and the CPGs do not focus on prevention and vaccination.
Journal ArticleDOI
Replication of hepatitis C virus
TL;DR: The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps.
Journal ArticleDOI
Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study
Andri Rauch,Zoltán Kutalik,Zoltán Kutalik,Patrick Descombes,Tao Cai,Julia di Iulio,Tobias Mueller,Murielle Bochud,Manuel Battegay,Enos Bernasconi,Jan Borovicka,Sara Colombo,Andreas Cerny,Jean-François Dufour,Hansjakob Furrer,Huldrych F. Günthard,Markus H. Heim,Bernard Hirschel,Raffaele Malinverni,Darius Moradpour,Beat Müllhaupt,Andrea Witteck,Jacques S. Beckmann,Jacques S. Beckmann,Thomas Berg,Sven Bergmann,Sven Bergmann,Francesco Negro,Amalio Telenti,Pierre-Yves Bochud +29 more
TL;DR: The association of the IL28B locus with natural and treatment-associated control of HCV indicates the importance of innate immunity and interferon lambda in the pathogenesis ofHCV infection.
Journal ArticleDOI
Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex
Denise Egger,Benno Wölk,Rainer Gosert,Rainer Gosert,Leonardo Bianchi,Hubert E. Blum,Darius Moradpour,Kurt Bienz +7 more
TL;DR: It is proposed that the membranous web forms the viral replication complex in HCV-infected cells.