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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Journal ArticleDOI
Cardiovascular effects of melanocortins
TL;DR: The salt-sensitive hypertension in rodents with impaired γ-MSH signaling appears due to stimulation of noradrenergic activity, and is accompanied by insulin resistance, an observation which offers a new window into the study of the association of salt- sensitive hypertension with insulin resistance and type II diabetes.
Journal ArticleDOI
The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis.
Yannick Romero,Mavunza Livia Vuandaba,Philippe Suarez,Corinne Grey,Pierre Calvel,Béatrice Conne,David A. Pearce,B de Massy,Edith Hummler,Serge Nef +9 more
TL;DR: Alterations observed in the glucocorticoid-induced leucine zipper protein (GILZ) encoded by the X-linked Tsc22d3 (Gilz) gene included extensive apoptosis at the spermatogonial level and meiotic arrest in the mid-late zygotene stage, emphasizing the essential role played by GILZ in mediating sperMatogonial survival and s permatogenesis.
Proceedings ArticleDOI
New approaches to improve the detection of eutrophication in UK coastal waters
David Mills,Naomi Greenwood,Silke Kröger,Michelle Devlin,D. B. Sivyer,David A. Pearce,S.J. Cutchey,S.J. Malcolm +7 more
TL;DR: In this article, the authors describe the pilot application of in situ monitoring technology (SmartBuoy), which is deployed in the southern North Sea and a third in Liverpool Bay (Irish Sea).
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Tissue-specific variation in nonsense mutant transcript level and drug-induced read-through efficiency in the Cln1(R151X) mouse model of INCL.
TL;DR: This study identifies a new challenge/hurdle for read‐through drug therapy: variable efficiency of read-through therapy in the different tissues/organs because of tissue‐specific variations in nonsense mutant transcript levels.
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Preliminary Analysis of Life within a Former Subglacial Lake Sediment in Antarctica
TL;DR: The first microbiological analysis of a sample taken from a former subglacial lake sediment in Antarctica (Lake Hodgson, on the Antarctic Peninsula) is reported, indicating these are diverse ecosystems with enormous potential.