D
David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
Papers
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Journal ArticleDOI
AMP-activated Kinase Inhibits the Epithelial Na+ Channel through Functional Regulation of the Ubiquitin Ligase Nedd4-2
Vivek Bhalla,Nicholas M. Oyster,Adam Fitch,Marjolein A. Wijngaarden,Dietbert Neumann,Uwe Schlattner,David A. Pearce,Kenneth R. Hallows +7 more
TL;DR: The role of Nedd4-2 in the regulation of ENaC by AMP-activated kinase (AMPK) was examined in Xenopus oocytes co-expressing ENaCs and wild-type (WT) or mutant forms of the ubiquitin ligase Nedd 4-2.
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Late onset neurodegeneration in the Cln3 -/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation
Charlie C. Pontikis,Claire V. Cella,Nisha Parihar,Ming K. Lim,Shubhodeep Chakrabarti,Hannah M. Mitchison,William C. Mobley,Payam Rezaie,Payam Rezaie,David A. Pearce,Jonathan D. Cooper +10 more
TL;DR: In this article, a detailed morphological characterization of the Cln3 null mutant (Cln3(-/-)) mouse model of juvenile ceroid lipofuscinosis (JNCL) was conducted, which revealed a delayed onset neurodegenerative phenotype with no significant regional atrophy, but with widespread loss of hippocampal interneurons.
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The Serum and Glucocorticoid-Inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1
C. Chris Yun,Monica Palmada,Hamdy M. Embark,Olga Yu Fedorenko,Yuxi Feng,Guido Henke,Iwan Setiawan,Christoph Boehmer,Edward J. Weinman,Sabrina Sandrasagra,Christoph Korbmacher,Philip Cohen,David A. Pearce,Florian Lang +13 more
TL;DR: NHERF2 andSGK1 interact to enhance ROMK1 activity in large part by enhancing the abundance of channel protein within the cell membrane, which allows the integration of genomic regulation and activation of SGK1 and NHERf2 in the control of ROMK 1 activity and renal K(+) excretion.
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Homodimerization of the Glucocorticoid Receptor Is Not Essential for Response Element Binding: Activation of the Phenylethanolamine N-Methyltransferase Gene by Dimerization-Defective Mutants
TL;DR: It is suggested that protein-DNA and protein-protein interactions that support such complexes are essential for activation of this type of gene, and that DNA binding of GR might be essential to survival.
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The biodiversity and ecology of Antarctic lakes: models for evolution
TL;DR: Molecular studies on Antarctic lake communities are still in their infancy, but there is clear evidence from some taxonomic groups, for example the Cyanobacteria, that there is endemicity.