D
David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
Papers
More filters
Journal ArticleDOI
The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems
Ainslie Tisdale,Christine M. Cutillo,Ramaa Nathan,Pierantonio Russo,Bryan Laraway,Melissa Haendel,Douglas Nowak,Cindy Hasche,Chun-Hung Chan,Emily R. Griese,Hugh Dawkins,Oodaye Shukla,David A. Pearce,David A. Pearce,Joni L. Rutter,Anne Pariser +15 more
TL;DR: In this paper, the authors performed a pilot IDeaS study, where they attempted to quantify the number of rare diseases (RD) patients and the direct medical costs of 14 representative RD patients within 4 different HCS databases and performed a preliminary analysis of the diagnostic journey for selected RD patients.
Journal ArticleDOI
Channeling studies in yeast: yeast as a model for channelopathies?
Devin M. Wolfe,David A. Pearce +1 more
TL;DR: The utility of using yeast as a model system for studying ion channels associated to human disease is illustrated using yeast lacking the GEF1 gene product that encodes the human homolog to the chloride channel CLC-3.
Journal ArticleDOI
Characterization of a novel N-acylhomoserine lactonase, AidP, from Antarctic Planococcus sp.
TL;DR: It is demonstrated that AidP is effective in attenuating the pathogenicity of P. carotovorum, a plant pathogen that causes soft-rot disease and the potential of this anti-quorum sensing agent to be safely applied in the field trials is indicated.
Journal ArticleDOI
Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.
Undine E. Lang,David P. Wolfer,Florian Grahammer,Nathalie Strutz-Seebohm,Guiscard Seebohm,Hans-Peter Lipp,James A. McCormick,Rainer Hellweg,Kevin Dawson,Jian Wang,David A. Pearce,Florian Lang +11 more
TL;DR: In conclusion, lack of SGK3 leads to subtle behavioral defects which may result from deranged neuronal regulation of transporters and ion channels.
Journal ArticleDOI
Akt2 and SGK3 are both determinants of postnatal hair follicle development
Theodora M. Mauro,James A. McCormick,James A. McCormick,Jian Wang,Krishna M. Boini,Leena Ray,Bobby R. Monks,Morris J. Birnbaum,Florian Lang,David A. Pearce +9 more
TL;DR: Akt2 and Akt2 both appear to play important roles in postnatal hair follicle morphogenesis, likely because of their redundant regulation of β‐catenin‐dependent transcriptional processes, which control hair follicles cell proliferation.