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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Exploration of Ellsworth Subglacial Lake: a concept paper on the development, organisation and execution of an experiment to explore, measure and sample the environment of a West Antarctic subglacial lake
Martin J. Siegert,A. Behar,Michael J. Bentley,David Blake,Stephen A. Bowden,Poul Christoffersen,Charles S. Cockell,Hugh F. J. Corr,David C. Cullen,Howell G. M. Edwards,A. Ellery,Cynan Ellis-Evans,Gwyn Griffiths,Richard C. A. Hindmarsh,Dominic A. Hodgson,Edward C. King,Henry F. Lamb,L. Lane,Keith Makinson,Matthew C. Mowlem,John Parnell,David A. Pearce,John C. Priscu,Andrés Rivera,Mark A. Sephton,Mark R. Sims,Andrew Smith,Martyn Tranter,Jemma L. Wadham,Gary S. Wilson,John Woodward +30 more
TL;DR: A consortium of over 20 scientists from seven countries and 14 institutions has been assembled to plan the exploration of Lake Ellsworth, a subglacial lake in West Antarctica, which has been hypothesised to house unique forms of life and hold detailed sedimentary records of past climate change.
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The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p
TL;DR: It is proposed that up-regulation of Btn2p in btn1-delta is an indicator of altered trafficking within the cell, and that altered intracellular trafficking may contribute to some of the cellular pathological hallmarks of this disease Batten disease.
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Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
TL;DR: The pathogenic potential of GAD autoantibodies is examined in light of what is known for other autoimmune disorders, such as multiple sclerosis, SPS, Rasmussen encephalitis, and type 1 diabetes, and may have radical implications for diagnosis and management of Batten disease.
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The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.
Philippe Suarez,Elena Gonzalez Rodriguez,Rama Soundararajan,Anne Marie Mérillat,Jean-Christophe Stehle,Samuel Rotman,Thierry Roger,Marie Jeanne Voirol,Jian Wang,Olaf Gross,Virginie Pétrilli,Karim Nadra,Anne Wilson,Friedrich Beermann,François P. Pralong,Marc Maillard,David A. Pearce,Roman Chrast,Bernard C. Rossier,Edith Hummler +19 more
TL;DR: The analysis of the Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis development.
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Isolation, Characterisation, and Lipase Production of a Cold-Adapted Bacterial Strain Pseudomonas sp. LSK25 Isolated from Signy Island, Antarctica.
Leelatulasi Salwoom,Leelatulasi Salwoom,Raja Noor Zaliha Raja Abd Rahman,Abu Bakar Salleh,Fairolniza Mohd Shariff,Peter Convey,David A. Pearce,David A. Pearce,Mohd Shukuri Mohamad Ali +8 more
TL;DR: This study focuses on bacterial strains isolated from anthropogenically-influenced soil samples collected around Signy Island Research Station, and found the highest level of sequence similarity to a Pseudomonas sp.