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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Journal ArticleDOI
Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis.
TL;DR: The renal adaptive response to metabolic acidosis involves increased cortical Na/H antiporter mRNA levels, and the enhanced proximal tubule Na/h antiporter activity and bicarbonate reabsorption in respiratory acidosis seem to involve mechanisms other than increased Na/ H antiporter gene expression.
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The structure and stability of the bacterioplankton community in Antarctic freshwater lakes, subject to extremely rapid environmental change.
TL;DR: Comparison of the results from lakes of different nutrient status suggest that increased levels of nutrient input, and in the timing and duration of ice cover will lead to marked changes in the structure and stability of the bacterioplankton community at existing levels of environmental change.
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Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration.
Cristy A. Ku,Sarah Hull,Gavin Arno,Ajoy Vincent,Keren J. Carss,Robert J. Kayton,Douglas A. Weeks,Glenn Anderson,Ryan D. Geraets,Camille Parker,David A. Pearce,Michel Michaelides,Robert E MacLaren,Anthony G. Robson,Graham E. Holder,Elise Héon,F. Lucy Raymond,Anthony T. Moore,Andrew R. Webster,Mark E. Pennesi +19 more
TL;DR: Detailed clinical, imaging, and genetic features of CLN3-associated nonsyndromic retinal degeneration are described, including significant photoreceptor loss except in patients with late-onset disease who had a focal preservation of the ellipsoid zone and outer nuclear layer in the fovea.
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Estimating the diffuse attenuation coefficient from optically active constituents in UK marine waters
Michelle Devlin,Jon Barry,David Mills,R. J. Gowen,Jo Foden,D. B. Sivyer,Naomi Greenwood,David A. Pearce,Paul Tett +8 more
TL;DR: In this paper, the attenuation of submarine photosynthetically active radiation (PAR) in relation to the concentrations of Optically Active Constituents (OACs) in a range of water types around the United Kingdom was investigated.
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mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel
TL;DR: MSIN1 is identified as the mTORC2 component that mediates interaction with SGK1 and it is demonstrated that this interaction is required forSGK1 phosphorylation and epithelial sodium channel activation, suggesting a mechanism for m TORC2 specificity in the regulation of diverse cellular processes.