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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease.
TL;DR: It is shown that acute inhibition of N-methyl-D-aspartate (NMDA)-type glutamate receptors by memantine had no effect on the impaired motor coordination of one-month-old Cln3(Δex1-6) mice, and NMDA receptors are identified as a new therapeutic target for juvenile Batten disease.
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Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3
Nathalie Strutz-Seebohm,Guiscard Seebohm,Andreas F. Mack,Hans Joachim Wagner,Lothar Just,Thomas Skutella,Undine E. Lang,Guido Henke,Marion Striegel,Michael Hollmann,Nathalie Rouach,Roger A. Nicoll,James A. McCormick,Jian Wang,David A. Pearce,Florian Lang +15 more
TL;DR: In Xenopus oocytes expressing the AMPA subunit GluR1, it is shown that SGK3, and to a lesser extent SGK2, but not SGK1, increase glutamate‐induced currents by increasing the abundance of GLUR1 protein in the cell membrane.
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Transcript and in silico analysis of CLN3 in juvenile neuronal ceroid lipofuscinosis and associated mouse models
TL;DR: Results indicate that the most common mutation associated with JNCL results in a loss of functional CLN3, that the Cln3(Deltaex1-6) mouse harbors a null ClN3 allele, and that it therefore represents a valid model for this disease.
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Protein Product of CLN6 Gene Responsible for Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis Interacts with CRMP-2
TL;DR: It is concluded that alterations in neurite maturation resulting from a loss of CLN6–CRMP‐2 interaction may contribute to neuronal dysfunction and pathology in vLINCL.
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A multi-site field evaluation of granular inoculants for legume nodulation
Matthew D. Denton,David A. Pearce,Ross Ballard,Murray C. Hannah,Lesley A. Mutch,Sorn Norng,Jo Slattery +6 more
TL;DR: It is demonstrated that certain granule types have the potential to be used in Australia with grain legumes, particularly in circumstances when seed-applied inoculants are problematic, such as where seed fungicides or insecticides need to be applied.