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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Journal ArticleDOI
A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies
Ryan D. Geraets,Logan Langin,Jacob T. Cain,Camille Parker,Rosanna Beraldi,Attila D. Kovács,Jill M. Weimer,David A. Pearce +7 more
TL;DR: A mouse model that carries a mutation equivalent to the human p.R208X mutation is created that can be used for the preclinical evaluation of all therapeutic approaches including mutation guided therapies in CLN2 disease.
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SCUBA divers as oceanographic samplers: The potential of dive computers to augment aquatic temperature monitoring.
Serena Wright,Tom Hull,D. B. Sivyer,David A. Pearce,John K. Pinnegar,John K. Pinnegar,Martin Sayer,Andrew O. M. Mogg,Elaine Azzopardi,Steve Gontarek,Kieran Hyder +10 more
TL;DR: The results show that, with processing, dive computers can provide a useful and novel tool with which to augment existing monitoring systems all over the globe, but especially in under-sampled or highly changeable coastal environments.
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Planetary Protection and Mars Special Regions—A Suggestion for Updating the Definition
Petra Rettberg,Alexandre M. Anesio,Victor R. Baker,John A. Baross,Sherry L. Cady,Emmanouil Detsis,Christine M. Foreman,Ernst Hauber,Gian Gabriele Ori,David A. Pearce,Nilton O. Renno,Gary Ruvkun,Birgit Sattler,Mark P. Saunders,David H. Smith,Dirk Wagner,Frances Westall +16 more
TL;DR: This work highlights the role of COSPAR and the scientific community in defining and updating the framework of planetary protection and focuses on Mars "Special Regions," areas where strict planetary protection measures have to be applied before a spacecraft can explore them.
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Patterns of marine bacterioplankton biodiversity in the surface waters of the Scotia Arc, Southern Ocean
TL;DR: Spatial patchiness in marine surface bacterioplankton populations was investigated in the Southern Ocean, and results suggest that the dominant bacteriopLankton groups are consistent between locations, but significant differences may be detected across the rare biodiversity.
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Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.
TL;DR: It is determined that growing btn1-Delta strains in the presence of chloroquine reverses the resistance to ANP, decreases the rate of medium acidification, increases the activity of plasma membrane H(+)-ATPase, and elevates vacuolar pH.