David A. Pearce

TL;DR: Akt/PKBβ plays a role in the regulation of renal glucose transport and is studied in gene-targeted mice lacking functional Akt/P KBβ and in their wild-type littermates.

TL;DR: Paraplegin is highly homologous to a class of well studied yeast ATP-dependent zinc metalloproteases, which show 55%, 55% and 52% identity, respectively, to Afg3p, Rca1p and Yme1p in yeast.

TL;DR: The data support the idea that this exacerbation of the glucose-handling defect is due to impaired β-cell function, rather than increased insulin resistance in peripheral tissues, and suggest that SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within β-cells, to stimulate proliferation and insulin release.

TL;DR: The results show a prominent increase in AMPA receptor surface expression in the brain of Cln3(-/-) mice and suggest that CLN3 is involved in the regulation of AMPA receptors surface expression.

TL;DR: To date, wherever life has been sought on Earth, it has almost always been found—from high in the stratosphere to deep in the ocean trenches, as well as extensive work on permafrost communities and work in the deep sea, suggests that life can survive and potentially thrive in these types of environment.