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David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
Papers
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Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells.
TL;DR: Inhibition of steroid-regulated gene transcription by immunosuppressive agents may explain the electrolyte abnormalities seen in patients receiving these drugs.
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Diagnosis of Neuronal Ceroid Lipofuscinosis: Mutation Detection Strategies
TL;DR: In order to streamline the diagnostic process, the age of symptom onset, geography and/or ethnicity, and enzyme activity may be considered together and serve to guide the correct route to genetic confirmation of an NCL through mutational analysis.
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Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3
Venkanna Pasham,Anand Rotte,Madhuri Bhandaru,Melanie Eichenmüller,Henning Fröhlich,Andreas F. Mack,Diwakar Bobbala,Wenting Yang,David A. Pearce,Florian Lang +9 more
TL;DR: SGK3 suppresses gastric acid secretion, an effect presumably mediated by the stimulation of protein kinase A with the subsequent activation of K+ channels.
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Enhanced stability in vivo of a thermodynamically stable mutant form of yeast iso-1-cytochrome c.
David A. Pearce,Fred Sherman +1 more
TL;DR: The in vivo levels of the N57I and N57G iso-l-cytochrome c suggest that proteins in the mitochondrial intermembrane space can be subjected to degradation, and that this degradation may play a role in controlling their normal levels.
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Hydrothermal activity lowers trophic diversity in Antarctic hydrothermal sediments
James B. Bell,James B. Bell,James B. Bell,William D. K. Reid,David A. Pearce,Adrian G. Glover,C. J. Sweeting,Jason Newton,Clare Woulds +8 more
TL;DR: In this paper, a combination of microbial and biochemical data was used to assess trophodynamics between and within hydrothermal and background areas of the Bransfield Strait (1050-1647m of depth).