D
David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
Papers
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Journal ArticleDOI
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.
Vivek Bhalla,Dorothée Daidié,Hongyan Li,Alan C. Pao,Lila P. LaGrange,Jian Wang,Alain Vandewalle,James D. Stockand,Olivier Staub,David A. Pearce +9 more
TL;DR: It is shown that SGK1-mediated phosphorylation of Nedd4-2 induces its interaction with members of the 14-3-3 family of regulatory proteins, which provides a mechanism by which SGK 1 modulates the ENaC-mediated Na(+) current.
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The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action.
Aditi Bhargava,Meryl J. Fullerton,Kathy Myles,Timothy M Purdy,John W. Funder,David A. Pearce,Tim J Cole +6 more
TL;DR: The early onset of SGK induction in kidney and colon and the correlation with urinary changes in terms of both time course and dose response suggest that SGK plays an important role in mediating the effects of aldosterone on sodium homeostasis in vivo.
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SGK1 regulation of epithelial sodium transport.
TL;DR: SGK1 appears to have been implicated in membrane trafficking and possibly in the control of ion transport and cell volume in early single cell eukaryotes and in metazoan epithelia, it seems likely that SGK1 was adapted to the regulation of ions transport in response to hormonal and osmotic signals.
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Nonsense-mediated decay in genetic disease: friend or foe?
Jake N. Miller,David A. Pearce +1 more
TL;DR: The normal function of this RNA surveillance pathway and how it is regulated is reviewed, current evidence for the role that it plays in modulating genetic disease phenotypes is provided, and how NMD can be used as a therapeutic target is provided.
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Microorganisms in the atmosphere over Antarctica
David A. Pearce,Paul D. Bridge,Kevin A. Hughes,Birgit Sattler,Roland Psenner,Nicholas J. Russell +5 more
TL;DR: The behaviour of microorganisms in the Antarctic aerial environment is examined and the extent to which these microorganisms might influence Antarctic microbial biodiversity is examined.