D
David Twomey
Researcher at Broad Institute
Publications - 9
Citations - 3229
David Twomey is an academic researcher from Broad Institute. The author has contributed to research in topics: Haematopoiesis & Endothelial stem cell. The author has an hindex of 6, co-authored 8 publications receiving 3055 citations. Previous affiliations of David Twomey include Boston Children's Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Andrei V. Krivtsov,David Twomey,David Twomey,Zhaohui Feng,Matthew C. Stubbs,Yingzi Wang,Joerg Faber,Jason E. Levine,Jing Wang,William C. Hahn,William C. Hahn,D. Gary Gilliland,D. Gary Gilliland,Todd R. Golub,Todd R. Golub,Scott A. Armstrong +15 more
TL;DR: It is shown that leukaemia stem cells (LSC) can maintain the global identity of the progenitor from which they arose while activating a limited stem-cell- or self-renewal-associated programme.
Journal ArticleDOI
Characterizing the cancer genome in lung adenocarcinoma
Barbara A. Weir,Barbara A. Weir,Michele S. Woo,Gad Getz,Sven Perner,Sven Perner,Li Ding,Rameen Beroukhim,Rameen Beroukhim,William M. Lin,William M. Lin,Michael A. Province,Aldi T. Kraja,Laura A. Johnson,Kinjal Shah,Kinjal Shah,Mitsuo Sato,Roman K. Thomas,Justine A. Barletta,Ingrid B. Borecki,Stephen R. Broderick,Andrew C. Chang,Derek Y. Chiang,Derek Y. Chiang,Lucian R. Chirieac,Jeonghee Cho,Yoshitaka Fujii,Adi F. Gazdar,Thomas J. Giordano,Heidi Greulich,Heidi Greulich,Megan Hanna,Megan Hanna,Bruce E. Johnson,Mark G. Kris,Alex E. Lash,Ling Lin,Neal I. Lindeman,Elaine R. Mardis,John Douglas Mcpherson,John D. Minna,Margaret Morgan,Mark Nadel,Mark Nadel,Mark B. Orringer,John R. Osborne,Brad Ozenberger,Alex H. Ramos,Alex H. Ramos,James T. Robinson,Jack A. Roth,Valerie W. Rusch,Hidefumi Sasaki,Frances A. Shepherd,Carrie Sougnez,Margaret R. Spitz,Ming-Sound Tsao,David Twomey,Roel G.W. Verhaak,George M. Weinstock,David A. Wheeler,Wendy Winckler,Wendy Winckler,Akihiko Yoshizawa,Soyoung Yu,Maureen F. Zakowski,Qunyuan Zhang,David G. Beer,Ignacio I. Wistuba,Mark A. Watson,Levi A. Garraway,Levi A. Garraway,Marc Ladanyi,William D. Travis,William Pao,Mark A. Rubin,Mark A. Rubin,Stacey Gabriel,Richard A. Gibbs,Harold E. Varmus,Richard K. Wilson,Eric S. Lander,Eric S. Lander,Eric S. Lander,Matthew Meyerson,Matthew Meyerson +85 more
TL;DR: A large-scale project to characterize copy-number alterations in primary lung adenocarcinomas using dense single nucleotide polymorphism arrays identifies NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung carcinomas.
Journal ArticleDOI
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
Guo Wei,Guo Wei,David Twomey,David Twomey,Justin Lamb,Krysta D. Schlis,Jyoti Agarwal,Ronald W. Stam,Joseph T. Opferman,Stephen E. Sallan,Monique L. den Boer,Rob Pieters,Todd R. Golub,Scott A. Armstrong +13 more
TL;DR: Data indicate that MCL1 is an important regulator of GC-induced apoptosis and that the combination of rapamycin and glucocorticoids has potential utility in lymphoid malignancies.
Journal ArticleDOI
Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies
Eleni Tholouli,Judith A. Hoyland,Dolores Di Vizio,Fionnuala O'Connell,Sarah A. MacDermott,David Twomey,Richard M. Levenson,John A. Liu Yin,Todd R. Golub,Massimo Loda,Richard J. Byers +10 more
TL;DR: A methodology of multiplexed in situ hybridization (ISH) using a novel combination of quantum dot (QD)-labeled oligonucleotide probes and spectral imaging analysis in routinely processed, formalin-fixed paraffin embedded human biopsies is described.
Journal ArticleDOI
Evolving BioAssay Ontology (BAO): modularization, integration and applications
Saminda Abeyruwan,Uma D. Vempati,Hande Küçük-McGinty,Ubbo Visser,Amar Koleti,Ahsan Mir,Kunie Sakurai,Caty Chung,Joshua A. Bittker,Paul A. Clemons,Steve Brudz,Anosha Siripala,Arturo J. Morales,Martin Romacker,David Twomey,Svetlana Bureeva,Vance Lemmon,Vance Lemmon,Stephan C. Schürer +18 more
TL;DR: The evolution of BAO related to its formal structures, engineering approaches, and content is described to enable modeling of complex assays and integration with other ontologies and datasets to enable effective integration, aggregation, retrieval, and analyses of drug screening data.