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David Y. Takeda
Researcher at Harvard University
Publications - 27
Citations - 4649
David Y. Takeda is an academic researcher from Harvard University. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 16, co-authored 24 publications receiving 2781 citations. Previous affiliations of David Y. Takeda include University of Virginia & Broad Institute.
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Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Posted ContentDOI
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +51 more
TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
Mark Pomerantz,Fugen Li,David Y. Takeda,David Y. Takeda,Romina E. Lenci,Apurva Chonkar,Matthew S. Chabot,Paloma Cejas,Francisca Vazquez,Jennifer Cook,Ramesh A. Shivdasani,Michaela Bowden,Rosina T. Lis,William C. Hahn,William C. Hahn,Philip W. Kantoff,Myles Brown,Massimo Loda,Massimo Loda,Massimo Loda,Henry W. Long,Matthew L. Freedman,Matthew L. Freedman +22 more
TL;DR: It is shown that the androgen receptor (AR) cistrome undergoes extensive reprogramming during prostate epithelial transformation in man, and mechanistic insights are offered into a key set of events that drive normal prostate epithelium toward transformation and establish the centrality of epigenetic reprograming in human prostate tumorigenesis.
Journal ArticleDOI
Mutational processes shape the landscape of TP53 mutations in human cancer
Andrew O. Giacomelli,Andrew O. Giacomelli,Xiaoping Yang,Robert E. Lintner,James M. McFarland,Marc Duby,Jaegil Kim,Thomas P. Howard,Thomas P. Howard,David Y. Takeda,David Y. Takeda,Seav Huong Ly,Seav Huong Ly,Eejung Kim,Hugh S. Gannon,Hugh S. Gannon,Brian Hurhula,Ted Sharpe,Amy Goodale,Briana Fritchman,Scott Steelman,Francisca Vazquez,Francisca Vazquez,Aviad Tsherniak,Andrew J. Aguirre,Andrew J. Aguirre,John G. Doench,Federica Piccioni,Charles W. M. Roberts,Charles W. M. Roberts,Matthew Meyerson,Matthew Meyerson,Gad Getz,Cory M. Johannessen,David E. Root,William C. Hahn +35 more
TL;DR: Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus.
Journal ArticleDOI
A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer
David Y. Takeda,David Y. Takeda,Sándor Spisák,Ji-Heui Seo,Connor Bell,Edward P. O’Connor,Keegan Korthauer,Dezső Ribli,István Csabai,Norbert Solymosi,Zoltan Szallasi,Zoltan Szallasi,David R. Stillman,Paloma Cejas,Xintao Qiu,Henry W. Long,Viktoria Tisza,Viktoria Tisza,Pier Vitale Nuzzo,Pier Vitale Nuzzo,Mersedeh Rohanizadegan,Mersedeh Rohanizadegan,Mark Pomerantz,William C. Hahn,William C. Hahn,Matthew L. Freedman,Matthew L. Freedman +26 more
TL;DR: Epigenetic data generated in localized prostate tumors and benign specimens support the notion that this region is a developmental enhancer and highlight the importance of regulatory elements as highly recurrent oncogenic drivers.