David Y. Takeda

TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.

TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.

TL;DR: It is shown that the androgen receptor (AR) cistrome undergoes extensive reprogramming during prostate epithelial transformation in man, and mechanistic insights are offered into a key set of events that drive normal prostate epithelium toward transformation and establish the centrality of epigenetic reprograming in human prostate tumorigenesis.

TL;DR: Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus.

TL;DR: Epigenetic data generated in localized prostate tumors and benign specimens support the notion that this region is a developmental enhancer and highlight the importance of regulatory elements as highly recurrent oncogenic drivers.