D
Dominiek D. G. Despriet
Researcher at Erasmus University Rotterdam
Publications - 17
Citations - 1757
Dominiek D. G. Despriet is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Population & Factor H. The author has an hindex of 13, co-authored 17 publications receiving 1622 citations. Previous affiliations of Dominiek D. G. Despriet include Netherlands Institute for Neuroscience & Erasmus University Medical Center.
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Journal ArticleDOI
Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration.
Dominiek D. G. Despriet,Caroline C W Klaver,Jacqueline C.M. Witteman,Arthur A.B. Bergen,Isabella Kardys,Moniek P.M. de Maat,Sharmila S. Boekhoorn,Johannes R. Vingerling,Albert Hofman,Ben A. Oostra,André G. Uitterlinden,Theo Stijnen,Cornelia M. van Duijn,Paulus T. V. M. de Jong +13 more
TL;DR: The Rotterdam Study as discussed by the authors found that CFH Y402H polymorphism may account for a substantial proportion of AMD in individuals similar to those in the Rotterdean Study and may confer particular risk in the presence of environmental and genetic stimulators of complement cascade.
Journal ArticleDOI
Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene
Manfred Kayser,Fan Liu,A. Cecile J.W. Janssens,Fernando Rivadeneira,Oscar Lao,Kate van Duijn,Mark Vermeulen,Mark Vermeulen,Pascal P. Arp,Mila Jhamai,Wilfred F. J. van IJcken,Johan T. den Dunnen,Simon Heath,Diana Zelenika,Dominiek D. G. Despriet,Caroline C W Klaver,Johannes R. Vingerling,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Albert Hofman,Yurii S. Aulchenko,André G. Uitterlinden,Ben A. Oostra,Cornelia M. van Duijn +24 more
TL;DR: It is suggested that genetic variants regulating expression of the OCA2 gene exist in the HERC2 gene or, alternatively, within the 11.7 kb of sequence between OCA1 and HERC1, and that most iris color variation in Europeans is explained by those two genes.
Journal ArticleDOI
A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.
Abbas M Solouki,Virginie J. M. Verhoeven,Cornelia M. van Duijn,Annemieke J.M.H. Verkerk,M. Kamran Ikram,Pirro G. Hysi,Dominiek D. G. Despriet,Leonieke M E van Koolwijk,Lintje Ho,Wishal D. Ramdas,Monika A. Czudowska,Robert W A M Kuijpers,Najaf Amin,Maksim Struchalin,Yurii S. Aulchenko,Gabriel van Rij,Frans C. C. Riemslag,Terri L. Young,David A. Mackey,Tim D. Spector,Theo G. M. F. Gorgels,Jacqueline J. M. Willemse-Assink,Aaron Isaacs,Rogier Kramer,Sigrid M. A. Swagemakers,Arthur A.B. Bergen,Andy A.L.J. van Oosterhout,Ben A. Oostra,Fernando Rivadeneira,André G. Uitterlinden,Albert Hofman,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Christopher J Hammond,Johannes R. Vingerling,Caroline C W Klaver +35 more
TL;DR: The data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population, and appears to harbor regulatory elements which may influence transcription of these genes.
Journal ArticleDOI
Common genetic determinants of intraocular pressure and primary open-angle glaucoma
Leonieke M E van Koolwijk,Wishal D. Ramdas,M. Kamran Ikram,Nomdo M. Jansonius,Nomdo M. Jansonius,Francesca Pasutto,Pirro G. Hysi,Stuart MacGregor,Sarah F. Janssen,Alex W. Hewitt,Ananth C. Viswanathan,Jacoline B. ten Brink,S. Mohsen Hosseini,Najaf Amin,Dominiek D. G. Despriet,Jacqueline J. M. Willemse-Assink,Rogier Kramer,Fernando Rivadeneira,Maksim Struchalin,Yurii S. Aulchenko,Nicole Weisschuh,Matthias Zenkel,Christian Y. Mardin,Eugen Gramer,Ulrich Welge-Lussen,Grant W. Montgomery,Francis Carbonaro,Terri L. Young,Céline Bellenguez,Peter McGuffin,Paul J. Foster,Fotis Topouzis,Paul Mitchell,Jie Jin Wang,Jie Jin Wang,Tien Yin Wong,Monika A. Czudowska,Albert Hofman,André G. Uitterlinden,Roger C. W. Wolfs,Paulus T. V. M. de Jong,Ben A. Oostra,Andrew D. Paterson,David A. Mackey,Arthur A. B. Bergen,André Reis,Christopher J Hammond,Johannes R. Vingerling,Hans G Lemij,Caroline C W Klaver,Cornelia M. van Duijn +50 more
TL;DR: GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina, and both genes functionally interact with known glaucoma disease genes.
Journal ArticleDOI
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Pirro G. Hysi,Ching-Yu Cheng,Henriët Springelkamp,Stuart MacGregor,Jessica N. Cooke Bailey,Robert Wojciechowski,Robert Wojciechowski,Veronique Vitart,Abhishek Nag,Alex W. Hewitt,René Höhn,Cristina Venturini,Cristina Venturini,Alireza Mirshahi,Wishal D. Ramdas,Gudmar Thorleifsson,Eranga N. Vithana,Chiea Chuen Khor,Chiea Chuen Khor,Arni B Stefansson,Jiemin Liao,Jonathan L. Haines,Najaf Amin,Ya Xing Wang,Philipp S. Wild,Ayse Bilge Ozel,Jun Li,Brian W Fleck,Tanja Zeller,Sandra E Staffieri,Yik Ying Teo,Gabriel Cuellar-Partida,Xiaoyan Luo,R. Rand Allingham,Julia E. Richards,Andrea Senft,Lennart C. Karssen,Yingfeng Zheng,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Liang Xu,Adriana I Iglesias,James F. Wilson,Jae H. Kang,Elisabeth M. van Leeuwen,Vesteinn Jonsson,Unnur Thorsteinsdottir,Dominiek D. G. Despriet,Sarah Ennis,Sayoko E. Moroi,Nicholas G. Martin,Nomdo M. Jansonius,Seyhan Yazar,E-Shyong Tai,Philippe Amouyel,James F Kirwan,Leonieke M E van Koolwijk,Michael A. Hauser,Fridbert Jonasson,Paul Leo,Stephanie J. Loomis,Rhys Fogarty,Fernando Rivadeneira,Lisa S. Kearns,Karl J. Lackner,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Claire L. Simpson,Craig E. Pennell,Ben A. Oostra,André G. Uitterlinden,Seang-Mei Saw,Andrew J. Lotery,Joan E. Bailey-Wilson,Albert Hofman,Johannes R. Vingerling,Cécilia Maubaret,Cécilia Maubaret,Norbert Pfeiffer,Roger C. W. Wolfs,Hans G Lemij,Terri L. Young,Louis R. Pasquale,Louis R. Pasquale,Cécile Delcourt,Cécile Delcourt,Tim D. Spector,Caroline C W Klaver,Kerrin S. Small,Kathryn P. Burdon,Kari Stefansson,Tien Yin Wong,Ananth C. Viswanathan,David A. Mackey,David A. Mackey,Jamie E Craig,Janey L. Wiggs,Cornelia M. van Duijn,Christopher J Hammond,Tin Aung +100 more
TL;DR: The results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP were reported in this article.