D
Dong-Kug Choi
Researcher at Konkuk University
Publications - 195
Citations - 11563
Dong-Kug Choi is an academic researcher from Konkuk University. The author has contributed to research in topics: Neuroinflammation & Microglia. The author has an hindex of 48, co-authored 183 publications receiving 9927 citations. Previous affiliations of Dong-Kug Choi include Kyungpook National University & Columbia University.
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Journal ArticleDOI
The DNA sequence of human chromosome 21
Masahira Hattori,Asao Fujiyama,Todd D. Taylor,Hidemi Watanabe,Tetsushi Yada,H.-S. Park,Atsushi Toyoda,Kazuo Ishii,Yasushi Totoki,Dong-Kug Choi,Eiichi Soeda,Misao Ohki,T. Takagi,Yoshiyuki Sakaki,S. Taudien,K. Blechschmidt,A. Polley,U. Menzel,Jean-Maurice Delabar,K. Kumpf,R. Lehmann,David Patterson,Kathrin Reichwald,Andreas Rump,M. Schillhabel,A. Schudy,W. Zimmermann,André Rosenthal,Jun Kudoh,Kazunori Shibuya,Kazuhiko Kawasaki,Shuichi Asakawa,Ai Shintani,Takashi Sasaki,Kentaro Nagamine,Susumu Mitsuyama,Stylianos E. Antonarakis,Shinsei Minoshima,Nobuyoshi Shimizu,Gabriele Nordsiek,K. Hornischer,P. Brandt,M. Scharfe,O. Schön,A. Desario,J. Reichelt,G. Kauer,H. Blöcker,Juliane Ramser,Alfred Beck,Sven Klages,Steffen Hennig,L. Riesselmann,Emilie Dagand,Thomas Haaf,S. Wehrmeyer,K. Borzym,Katheleen Gardiner,Dean Nizetic,Fiona Francis,Hans Lehrach,Richard Reinhardt,Marie-Laure Yaspo +62 more
TL;DR: In this article, the authors reported the sequence and gene catalogue of the long arm of chromosome 21 and sequenced 33,546,361 base pairs (bp) of DNA with very high accuracy, the largest contig being 25,491,867 bp.
Journal ArticleDOI
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
Du Chu Wu,Vernice Jackson-Lewis,Miquel Vila,Kim Tieu,Peter Teismann,Caryn Vadseth,Dong-Kug Choi,Harry Ischiropoulos,Serge Przedborski +8 more
TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.
Journal ArticleDOI
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
Peter Teismann,Kim Tieu,Dong-Kug Choi,Du-Chu Wu,Ali Naini,Stéphane Hunot,Miquel Vila,Vernice Jackson-Lewis,Serge Przedborski +8 more
TL;DR: It is demonstrated that targeting COX-2 does not protect against MPTP-induced dopaminergic neurodegeneration by mitigating inflammation, and evidence is provided that COx-2 inhibition prevents the formation of the oxidant species dopamine-quinone, which has been implicated in the pathogenesis of PD.
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Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease
Gabriella Gárdián,Susan E. Browne,Dong-Kug Choi,Péter Klivényi,Jason Gregorio,James K. Kubilus,James K. Kubilus,Hoon Ryu,Hoon Ryu,Brett Langley,Rajiv R. Ratan,Rajiv R. Ratan,Robert J. Ferrante,Robert J. Ferrante,M. Flint Beal +14 more
TL;DR: Results show that administration of phenylbutyrate, at doses that are well tolerated in man, exerts significant neuroprotective effects in a transgenic mouse model of HD, and therefore represents a very promising therapeutic approach for HD.
Journal ArticleDOI
The role of glial cells in Parkinson's disease.
Miquel Vila,Vernice Jackson-Lewis,Christelle Guégan,Du Chu Wu,Peter Teismann,Dong-Kug Choi,Kim Tieu,Serge Przedborski +7 more
TL;DR: The potential protective and deleterious effects of glial cells in the substantia nigra pars compacta of Parkinson's disease are reviewed.