E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal ArticleDOI
High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study.
C. Chabannon,Kenneth Cornetta,Jean-Pierre Lotz,C. Rosenfeld,M. Shlomchik,S. Yanovitch,Jean-Pierre Marolleau,George W. Sledge,G Novakovitch,Edward F. Srour,Barbara Burtness,J. Camerlo,Gwenaelle Gravis,J. Lee-Fischer,Catherine Faucher,I Chabbert,Diane S. Krause,Dominique Maraninchi,B Mills,LK Kunkel,F. Oldham,D. Blaise,Patrice Viens +22 more
TL;DR: It is concluded that selected CD34+ cells safely support haematopoietic recovery following high-dose chemotherapy in patients with poor-prognosis breast cancer.
Journal ArticleDOI
Hematopoietic cell regulation of osteoblast proliferation and differentiation.
TL;DR: The impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopolietic cell–derived OCs on OB proliferation, differentiation, and function are examined.
Journal ArticleDOI
Circulating hematopoietic stem cells serve as novel targets for in utero gene therapy
Barbara Murdoch,Lisa Gallacher,C. Awaraji,David A. Hess,M. Keeney,K. Jay,Kristin Chadwick,S. R. Foley,Kang Howson-Jan,I. Chin Yee,D.M. Wu,Edward F. Srour,Fraser Fellows,Mickie Bhatia +13 more
TL;DR: The findings indicate that active, transducible hematopoietic reconstituting cells are present in the circulation of the human fetus and that they represent novel target cells for future in utero gene therapy trials using autologous transplantation.
Journal ArticleDOI
Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation
Yi Zeng,Hal E. Broxmeyer,Karl Staser,Brahmananda R. Chitteti,Su Jung Park,Seongmin Hahn,Scott Cooper,Zejin Sun,Li Jiang,Xianlin Yang,Jin Yuan,Rachelle Kosoff,George E. Sandusky,Edward F. Srour,Jonathan Chernoff,D. Wade Clapp +15 more
TL;DR: Using a conditional Pak2 knockout mouse model, it is found that disruption of Pak2 in HSCs induced profound leukopenia and a mild macrocytic anemia, which may suggest underlying mechanisms by which Pak2 regulates granulocyte‐monocyte lineage commitment.
Journal ArticleDOI
Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma
Linlin Xu,Khalid S. Mohammad,Hao Wu,Colin D. Crean,Bradley Poteat,Yinghua Cheng,Angelo A. Cardoso,Christophe Machal,Helmut Hanenberg,Helmut Hanenberg,Rafat Abonour,Melissa A. Kacena,John M. Chirgwin,John M. Chirgwin,Attaya Suvannasankha,Attaya Suvannasankha,Edward F. Srour +16 more
TL;DR: In this article, the authors found evidence of a major role for the cell adhesion molecule CD166, which was found to be highly expressed in MM cell lines and primary bone marrow (BM) cells from patients.