E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal Article
Human CD34+ HLA-DR- bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis.
TL;DR: It is demonstrated that human CD34+ HLA-DR- marrow cells and their subsets contain primitive multipotential hematopoietic cells capable of self-renewal and of differentiation into multiple hematopolietic lineages.
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Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner
Lin Wang,Huajia Zhang,Sonia Rodríguez,Liyun Cao,Jonathan Parish,Christen L. Mumaw,Amy Zollman,Malgorzata M. Kamoka,Jian Mu,Danny Z. Chen,Edward F. Srour,Brahmananda R. Chitteti,Harm HogenEsch,Xiaolin Tu,Teresita Bellido,H. Scott Boswell,Taghi Manshouri,Srdan Verstovsek,Mervin C. Yoder,Reuben Kapur,Angelo A. Cardoso,Nadia Carlesso +21 more
TL;DR: The Notch/miR-155/κB-Ras1/NF-κB axis regulates the inflammatory state of the BM niche and affects the development of myeloproliferative disorders.
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Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle.
Christie M. Orschell-Traycoff,Kelly Hiatt,Ramzi Dagher,Susan Rice,Mervin C. Yoder,Edward F. Srour +5 more
TL;DR: A theoretical phenotype of a Sca-1(+)lin(-) engrafting cell is defined as one that is mitotically quiescent, CD43(+), CD49e(+, CD11a(-, CD49d(dim), and CD62L(-) and kinetics of in vitro proliferation may be a good predictor of engraftment potential of candidate populations of HSCs.
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Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis
TL;DR: Cell tracking with the membrane dye PKH2, immunostaining for CD34, and limiting dilution analysis was combined to estimate the frequency of long-term hematopoietic culture-initiating cells (LTHC-ICs) among de novo-generated CD34+ cells.
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Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro
TL;DR: Data show that CD34+ HLA-DR- CD15- rhodamine 123dull cells represent a fraction of human bone marrow highly enriched for HPP-CFC and that based on their regeneration and proliferative capacities, a hierarchy of HPP -CFC exists.