E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal ArticleDOI
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
Haiming Xu,Satyam Eleswarapu,Hartmut Geiger,Kathleen Szczur,Deidre Daria,Yi Zheng,Jeffrey Settleman,Edward F. Srour,David A. Williams,Marie Dominique Filippi +9 more
TL;DR: It is shown that loss of p190-B RhoGTPase activating protein, a negative regulator of Rho GTPases, results in enhanced long-term engraftment during serial transplantation, and this effect is associated with maintenance of functional HSC-enriched cells.
Journal ArticleDOI
Rapid engraftment after allogeneic transplantation using CD34-enriched marrow cells.
K Cornetta,V Gharpure,B Mills,Robert Hromas,Rafat Abonour,E. R. Broun,C. M. Traycoff,Mark P. Hanna,N Wyman,Constance Danielson,René Gonin,LK Kunkel,F. Oldham,Edward F. Srour +13 more
TL;DR: 14 patients who underwent HLA-identical sibling-matched alloBMT with marrow-enriched for CD34 cells using the Isolex 300 SA device are reported, finding CD34 selection in allo BMT permits rapid engraftment without unanticipated toxicities.
Journal ArticleDOI
Signaling Pathways Involved in Megakaryocyte-Mediated Proliferation of Osteoblast Lineage Cells
Ying Hua Cheng,Drew A. Streicher,David L. Waning,Brahmananda R. Chitteti,Rita Gerard-O'Riley,Mark C. Horowitz,Joseph P. Bidwell,Fredrick M. Pavalko,Edward F. Srour,Lindsey D. Mayo,Melissa A. Kacena,Melissa A. Kacena +11 more
TL;DR: Overall, the findings show that OBs respond to the presence of MKs, in part, via an integrin‐mediated signaling mechanism, activating a novel response axis that de‐represses cell cycle activity.
Journal ArticleDOI
Negative regulation of MHC class II gene expression by CXCR4.
Carol Sheridan,Miral Sadaria,Poornima Bhat-Nakshatri,Robert J. Goulet,Howard J. Edenberg,Brian P. McCarthy,Cheong Hee Chang,Edward F. Srour,Harikrishna Nakshatri +8 more
TL;DR: CXCR4 may influence the immune system under physiologic and pathologic conditions through negative regulation of MHC class II expression, possibly through PKA and SRC kinase.
Journal ArticleDOI
Characterization of normal human CD3+ CD5‐ and γδ T cell receptor positive T lymphocytes
TL;DR: Observations indicate that γδ is preferentially expressed on CD5‐negative or weakly positive T lymphocytes and that CD3+CD5‐γδ cells appear to constitute a discrete small subset of mature T lymphocyte which are cytotoxic in nature.