E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal ArticleDOI
Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
David J. Olivos,Marta Alvarez,Ying-Hua Cheng,Richard Adam Hooker,Wendy A. Ciovacco,Monique Bethel,Haley McGough,Christopher Yim,Brahmananda R. Chitteti,Pierre P. Eleniste,Mark C. Horowitz,Edward F. Srour,Angela Bruzzaniti,Robyn K. Fuchs,Melissa A. Kacena +14 more
TL;DR: In this article, the Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor.
Journal ArticleDOI
Leptin receptor, a surface marker for a subset of highly engrafting long-term functional hematopoietic stem cells
Thao Trinh,James Ropa,Arafat Aljoufi,Scott Cooper,Anthony L. Sinn,Edward F. Srour,Hal E. Broxmeyer +6 more
TL;DR: Although Lepr+HSCs represent a minor subset of HSCs, they are highly engrafting cells that possess embryonic-like transcriptomic characteristics, and that Lepr can serve as a reliable marker for functional long-term H SCs, which may have potential clinical applicability.
Journal ArticleDOI
Interaction of the inflammatory response and megakaryocytes in COVID-19 infection.
Hanisha L. Battina,Vincent J. Alentado,Edward F. Srour,Alison R. Moliterno,Melissa A. Kacena +4 more
Individualized breast cancer characterization through single cell analysis of tumor and adjacent-normal cells
Manjushree Anjanappa,Angelo A. Cardoso,Lijun Cheng,Safa F. Mohamad,Andrea M. Gunawan,Susan Rice,Yan Dong,Lang Li,George E. Sandusky,Edward F. Srour,Harikrishna Nakshatri +10 more
TL;DR: Single-cell genomics of breast tumors and adjacent normal cells propagated for a short duration under growth conditions that enable epithelial reprogramming enable more precise identification of cancer-deregulated genes, allow for early identification of therapeutically targetable tumor cell subpopulations, and ultimately provide a refinement of precision therapeutics for cancer treatment.
Journal ArticleDOI
Neonatal Osteomacs and Bone Marrow Macrophages Differ in Phenotypic Marker Expression and Function.
Safa F. Mohamad,Andrea M. Gunawan,Rachel J. Blosser,Paul Childress,Alexandra Aguilar-Perez,Joydeep Ghosh,Jung Min Hong,Jianyun Liu,Deepa Kanagasabapathy,Melissa A. Kacena,Edward F. Srour,Angela Bruzzaniti +11 more
TL;DR: In this paper, single-cell quantitative RT-PCR, mass cytometry (CyTOF), and marker-specific functional studies that further identify differences between OM and BM Mφ from neonatal C57Bl/6 mice.