E
Edward F. Srour
Researcher at Indiana University
Publications - 204
Citations - 10614
Edward F. Srour is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 51, co-authored 202 publications receiving 9991 citations. Previous affiliations of Edward F. Srour include Indiana University – Purdue University Indianapolis & University of New Mexico.
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Journal ArticleDOI
Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells.
Manjushree Anjanappa,Angelo A. Cardoso,Lijun Cheng,Safa F. Mohamad,Andrea M. Gunawan,Susan Rice,Yan Dong,Lang Li,George E. Sandusky,Edward F. Srour,Harikrishna Nakshatri +10 more
TL;DR: In this article, a single-cell genomics of breast tumors and adjacent normal cells propagated for a short duration under growth conditions that enable epithelial reprogramming was performed, where cells analyzed were either unselected for a specific subpopulation or phenotypically defined as undifferentiated and highly clonogenic ALDH+/CD49f+/EpCAM+ luminal progenitors.
Journal ArticleDOI
Animal models for human hematopoiesis.
TL;DR: The development, peculiarities, shortcomings, and applications of human-animal models as well as their potential use in exploring the field of human lymphohematopoiesis are the focus of this review.
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Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis.
Marta B. Alvarez,Linlin Xu,Paul Childress,Kevin A. Maupin,Safa F. Mohamad,Brahmananda R. Chitteti,Evan R. Himes,David J. Olivos,Ying Hua Cheng,Simon J. Conway,Edward F. Srour,Melissa A. Kacena +11 more
TL;DR: In this article, the loss of megakaryocytes (MK) negatively impacts osteoblastogenesis and hematopoiesis, and a significant 20-fold increase in femoral midshaft bone volume.
Journal ArticleDOI
Expansion of prostate epithelial progenitor cells after inflammation of the mouse prostate.
Liang Wang,Marloes Zoetemelk,Brahmananda R. Chitteti,Timothy L. Ratliff,Jason D. Myers,Edward F. Srour,Hal E. Broxmeyer,Travis J. Jerde +7 more
TL;DR: In this paper, a novel epithelial progenitor cell population is induced to expand during inflammation, and this population is increased in bacterially induced inflamed mouse prostates relative to naive control prostates.
Journal ArticleDOI
Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass.
Kevin A. Maupin,Evan R. Himes,Artur P. Plett,Hui Lin Chua,Pratibha Singh,Joydeep Ghosh,Safa F. Mohamad,Irushi Abeysekera,Alexa Fisher,Carol H. Sampson,Jung Min Hong,Paul Childress,Marta B. Alvarez,Edward F. Srour,Angela Bruzzaniti,Louis M. Pelus,Christie M. Orschell,Melissa A. Kacena +17 more
TL;DR: In this paper, the ability of megakaryocytes (MKs) to support osteoblast proliferation was attenuated during aging as transplantation of GATA1low/low hematopoietic donor cells from young mice resulted in an increase in bone mass of recipient mice compared to transplanting of young wild-type donor cells.