Quan Long

TL;DR: The landscape of gene expression across tissues is described, thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants are cataloged, complex network relationships are described, and signals from genome-wide association studies explained by eQTLs are identified.

TL;DR: Pindel, a pattern growth approach, is presented, to detect breakpoints of large deletions and medium-sized insertions from paired-end short reads and to demonstrate the efficiency of the computer program and accuracy of the results.

TL;DR: A map of unbalanced SVs is constructed based on whole genome DNA sequencing data from 185 human genomes, integrating evidence from complementary SV discovery approaches with extensive experimental validations, and serves as a resource for sequencing-based association studies.

TL;DR: This work catalogueed age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project, finding the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondrial biology is observed in many tissues.

TL;DR: Simulations suggest that the proposed multi-locus mixed model as a general method for mapping complex traits in structured populations outperforms existing methods in terms of power as well as false discovery rate.