E
Elphège P. Nora
Researcher at University of California, San Francisco
Publications - 51
Citations - 7716
Elphège P. Nora is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: CTCF & Chromatin. The author has an hindex of 23, co-authored 44 publications receiving 6133 citations. Previous affiliations of Elphège P. Nora include Cold Spring Harbor Laboratory & Curie Institute.
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Journal ArticleDOI
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphège P. Nora,Bryan R. Lajoie,Edda G. Schulz,Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Ikuhiro Okamoto,Ikuhiro Okamoto,Ikuhiro Okamoto,Nicolas Servant,Nicolas Servant,Nicolas Servant,Tristan Piolot,Tristan Piolot,Tristan Piolot,Nynke L. van Berkum,Johannes Meisig,John W. Sedat,Joost Gribnau,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Nils Blüthgen,Job Dekker,Edith Heard,Edith Heard,Edith Heard +26 more
TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
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Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Elphège P. Nora,Anton Goloborodko,Anne-Laure Valton,Johan H. Gibcus,Alec Uebersohn,Nezar Abdennur,Job Dekker,Leonid A. Mirny,Benoit G. Bruneau +8 more
TL;DR: The data support that CTCF mediates transcriptional insulator function through enhancer blocking but not as a direct barrier to heterochromatin spreading, and provides new fundamental insights into the rules governing mammalian genome organization.
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Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription
Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Rafael Galupa,Rafael Galupa,Rafael Galupa,Elphège P. Nora,Tristan Piolot,Tristan Piolot,Tristan Piolot,Job Dekker,Guido Tiana,Edith Heard +12 more
TL;DR: It is demonstrated that contacts between potential regulatory elements occur in the context of fluctuating structures rather than stable loops and proposed that such fluctuations may contribute to asymmetric expression in the Xic during X inactivation.
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CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation
TL;DR: Recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes are reviewed, and mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes are discussed.
Journal ArticleDOI
Regulation of X-chromosome inactivation by the X-inactivation centre
TL;DR: The recent discovery of the plasticity of the inactive state during early development, or during cloning, and induced pluripotency have contributed to the X chromosome becoming a gold standard in reprogramming studies.