Franz Fazekas

TL;DR: The histopathologic changes associated with incidental white matter signal hyperintensities on MRIs from 11 elderly patients are related to a descriptive classification for such abnormalities, and this classification appears to reflect both the different etiologies and severities of incidental MRI signal abnormalities, if it is modified to treat irregular periventricular and confluent deep white matter hyperintENSities together.

TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.

TL;DR: Small areas of signal loss on gradient echo T2*-weighted MR images indicate previous extravasation of blood and are related to bleeding-prone microangiopathy of different origins.

TL;DR: In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion‐weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days.

TL;DR: Target mismatch patients who had early reperfusion after endovascular stroke treatment had more favourable clinical outcomes and a randomised controlled trial of endov vascular treatment for patients with the target mismatch profile is warranted.