J
Jacob Marstrand
Researcher at Copenhagen University Hospital
Publications - 11
Citations - 1354
Jacob Marstrand is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Fluid-attenuated inversion recovery & Stroke. The author has an hindex of 6, co-authored 9 publications receiving 972 citations. Previous affiliations of Jacob Marstrand include University of Hamburg & Hvidovre Hospital.
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Journal ArticleDOI
MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
Götz Thomalla,Claus Z. Simonsen,Florent Boutitie,Grethe Andersen,Yves Berthezène,Bastian Cheng,Bharath Kumar Cheripelli,Tae-Hee Cho,Franz Fazekas,Jens Fiehler,Ian Ford,Ivana Galinovic,Susanne Gellissen,Amir Golsari,Johannes Gregori,Matthias Günther,Jorge Guibernau,Karl Georg Häusler,M. Hennerici,André Kemmling,Jacob Marstrand,Boris Modrau,Lars Neeb,Natalia Pérez de la Ossa,Josep Puig,Peter Ringleb,Pascal Roy,Enno Scheel,Wouter J. Schonewille,Joaquín Serena,Stefan Sunaert,Kersten Villringer,Anke Wouters,Vincent Thijs,Martin Ebinger,Matthias Endres,Jochen B. Fiebach,Robin Lemmens,Keith W. Muir,N. Nighoghossian,Salvador Pedraza,Christian Gerloff +41 more
TL;DR: In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion‐weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days.
Journal ArticleDOI
Cerebral Perfusion and Cerebrovascular Reactivity Are Reduced in White Matter Hyperintensities
Jacob Marstrand,Ellen Garde,Egill Rostrup,P. Ring,Simon Rosenbaum,Erik Lykke Mortensen,H.B.W. Larsson +6 more
TL;DR: Results show that a change in the hemodynamic status is present within the WMH, making these areas more likely to be exposed to transient ischemia inducing myelin rarefaction, and MRI may be used to examine the effect of therapeutic strategies designed to prevent or normalize vascular changes.
Journal ArticleDOI
Paroxysmal atrial fibrillation occurs often in cryptogenic ischaemic stroke. Final results from the SURPRISE study
Louisa M. Christensen,Derk W. Krieger,Søren Højberg,Ole Pedersen,Finn M. Karlsen,Martin Jacobsen,R. Worck,Henrik Nielsen,Karen Lehrmann Ægidius,L. L. Jeppesen,Sverre Rosenbaum,Jacob Marstrand,Hanne Christensen +12 more
TL;DR: The SURPRISE project aimed at determining the prevalence of asymptomatic paroxysmal atrial fibrillation in CS using long‐term cardiac monitoring.
Journal ArticleDOI
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
Götz Thomalla,Florent Boutitie,Henry Ma,Masatoshi Koga,Peter A. Ringleb,Lee H. Schwamm,Ona Wu,Martin Bendszus,Christopher F. Bladin,Bruce C.V. Campbell,Bastian Cheng,Leonid Churilov,Martin Ebinger,Martin Ebinger,Matthias Endres,Jochen B. Fiebach,Mayumi Fukuda-Doi,Manabu Inoue,Timothy Kleinig,Lawrence L. Latour,Robin Lemmens,Robin Lemmens,Christopher R Levi,Didier Leys,Kaori Miwa,Carlos A. Molina,Keith W. Muir,Norbert Nighoghossian,Mark W Parsons,Salvador Pedraza,Peter D. Schellinger,Stefan Schwab,Claus Z Simonsen,Shlee S. Song,Vincent Thijs,Vincent Thijs,Danilo Toni,Chung Y. Hsu,Nils Wahlgren,Haruko Yamamoto,Nawaf Yassi,Nawaf Yassi,Sohei Yoshimura,Steven Warach,Werner Hacke,Kazunori Toyoda,Geoffrey A. Donnan,Stephen M. Davis,Christian Gerloff,Boris Raul Acosta,Karen Aegidius,Christian Albiker,Anna Alegiani,Miriam Almendrote,Angelika Alonso,Katharina Althaus,Pierre Amarenco,Hemasse Amiri,Bettina Anders,Adriana Aniculaesei,Jason P. Appleton,Juan F. Arenillas,Christina Back,Christian Bähr,Jürgen Bardutzky,Flore Baronnet-Chauvet,R. Bathe-Peters,Anna Bayer-Karpinska,Juan L. Becerra,Christoph Beck,Olga Belchí Guillamon,Amandine Benoit,Nadia Berhoune,Daniela Bindila,Julia Birchenall,Karine Blanc-Lasserre,Miguel Blanco Gonzales,Tobias Bobinger,Ulf Bodechtel,E Bodiguel,Urszula Bojaryn,Louise Bonnet,Benjamin Bouamra,Paul Bourgeois,Lorenz Breuer,Ludovic Breynaert,David Broughton,Raf Brouns,Sébastian Brugirard,Bart Bruneel,Florian Buggle,Serkan Cakmak,Ana Calleja,David Calvet,David Carrera,Hsin Chieh Chen,Bharath Kumar Cheripelli,Tae Hee Cho,Chi un Choe,Lillian Choy,Hanne Christensen,Mareva Ciatipis,Geoffrey Cloud,Julien Cogez,Elisa Cortijo,Sophie Crozier,Dorte Damgaard,Krishna A Dani,Beatrijs De Coene,Isabel De Hollander,Jacques De Keyser,Nina De Klippel,Charlotte De Maeseneire,Ann De Smedt,Maria del Mar Castellanos Rodrigo,Sandrine Deltour,Jelle Demeestere,Laurent Derex,Philippe Desfontaines,Ralf Dittrich,Anand Dixit,Laurens Dobbels,V. Domigo,Laura Dorado,Charlotte Druart,Kristina Hougaard Dupont,Anne Dusart,Rainer Dziewas,Matthias Ebner,Myriam Edjali-Goujon,Philipp Eisele,Salwa El Tawil,Ahmed Elhfnawy,Ana Etexberria,Nick Evans,Simon Fandler,Franz Fazekas,Sandra Felix,Jens Fiehler,Alexandra Filipov,Katharina Filipski,Robert Fleischmann,Christian Foerch,Ian Ford,Alexandra Gaenslen,Ivana Galinovic,Elena Meseguer Gancedo,Ramanan Ganeshan,Carlos Garcia Esperon,Alicia Garrido,Thomas Gattringer,Olivia C. Geraghty,Rohat Geran,Stefan Gerner,S. Godon-Hardy,Jos Göhler,Amir Golsari,Meritxell Gomis,David Gorriz,Verena Gramse,Laia Grau,Martin Griebe,Cristina Guerrero,Damla Guerzoglu,Sophie Guettier,Vincent Guiraud,Christoph Gumbinger,Ignaz Gunreben,Florian Haertig,Christian Hametner,Bernard Hanseeuw,Andreas Hansen,Jakob Hansen,Thomas Harbo,Andreas Harloff,Peter Harmel,Karl Georg Häusler,Florian Heinen,Valentin Held,Simon Hellwig,Dimitri Hemelsoet,Michael G. Hennerici,Juliane Herm,Sylvia Hermans,Maria del C. Valdés Hernández,Jose Hervas Vicente,Niels Hjort,Cristina Hobeanu,Carsten Hobohm,Elmar Höfner,Katharina Hohenbichler,Marc Hommel,Julia Hoppe,Eva Hornberger,Carolin Hoyer,Xuya Huang,Nils Ipsen,Irina Isern,Lourdes Ispierto,Helle K. Iversen,Lise Jeppesen,Marta Jimenez,Jan Jungehülsing,Eric Jüttler,Dheeraj Kalladka,Bernd Kallmünzer,Arindam Kar,Lars Kellert,André Kemmling,Tobias Kessler,Usman A. Khan,Matthias Klein,Christoph Kleinschnitz,Matti Klockziem,Michael Knops,Luzie Koehler,Martin Koehrmann,Heinz Kohlfürst,Rainer Kollmar,Peter Kraft,Thomas Krause,Bo Kristensen,Jan M Kröber,Natalia Kurka,Alexandre Ladoux,Patrice Laloux,Catherine Lamy,Emmanuelle Landrault,Arne Lauer,Claire Lebely,Jonathan Leempoel,Kennedy R. Lees,Anne Leger,Laurence Legrand,Lin Li,Anna Mareike Löbbe,Frederic London,Elena López-Cancio,Matthias W. Lorenz,Stephen Louw,Caroline E. Lovelock,Manuel Lozano Sánchez,Giuseppe Lucente,Janos Lückl,Alain Luna,Kosmas Macha,Alexandre Machet,Daniel Mackenrodt,Dominik Madzar,Charles B. L. M. Majoie,Anika Männer,Vicky Maqueda,Jacob Marstrand,Alicia Martinez,Annika Marzina,Laura Mechthouff,Per Meden,Guy Meersman,Julia Meier,Charles Mellerio,Oliver Menn,Nadja Meyer,Dominik Michalski,Peter Michels,Lene Michelsen,Monica Millán Torne,Jens Minnerup,Boris Modrau,Sebastian Moeller,Anette Møller,Nathalie Morel,Fiona Moreton,Ludovic Morin,Thierry Moulin,Barry Moynihan,Anne K. Mueller,Patricia Mulero,Sibu Mundiyanapurath,Johannes Mutzenbach,Simon Nagel,Oliver Naggara,Arumugam Nallasivan,Irene Navalpotro,Alexander H. Nave,Paul J. Nederkoorn,Lars Neeb,Hermann Neugebauer,Tobias Neumann-Haefelin,Stefan Oberndorfer,Christian Opherk,Lorenz Oppel,Catherine Oppenheim,Johannes Orthgieß,Leif Østergaard,Perrine Paindeville,Ernest Palomeras,Verena Panitz,Bhavni Patel,André Peeters,Dirk Peeters,Anna Pellisé,Johann Pelz,Anthony C Pereira,Natalia Pérez de la Ossa,Richard J. Perry,Salvador Petraza,Stéphane Peysson,Waltraud Pfeilschifter,Alexander Pichler,Alexandra Pierskalla,Hans Werner Pledl,Sven Poli,Katrin Pomrehn,Marika Poulsen,Luis Prats,Silvia Presas,Elisabeth Prohaska,Volker Puetz,Josep Puig,Josep Puig Alcántara,Jan C. Purrucker,Veronique Quenardelle,Sankaranarayanan Ramachandran,Soulliard Raphaelle,Nicolas Raposo,Tilman Reiff,Michel J M Remmers,Pauline Renou,Martin Ribitsch,Hardy Richter,Martin Ritter,Thomas Ritzenthaler,Gilles Rodier,Christine Rodriguez-Régent,Manuel Rodríguez-Yáñez,Maria Roennefarth,Christine Roffe,Sverre Rosenbaum,Charlotte Rosso,Joachim Röther,Michal Rozanski,Noelia Ruiz de Morales,Francesca Russo,Matthieu Rutgers,Sharmilla Sagnier,Yves Samson,Josep Sánchez,Tamara Sauer,Jan H. Schäfer,Simon Schieber,Josef Schill,Dennis Schlak,Ludwig Schlemm,Sein Schmidt,Wouter J. Schonewille,Julian Schröder,Andreas Schulz,Johannes Schurig,Sönke Schwarting,Alexander Schwarz,Christopher Schwarzbach,Matthias Seidel,Alexander Seiler,Jochen Sembill,Joaquin Serena Leal,Ashit Shetty,Igor Sibon,Oliver C. Singer,Aravinth Sivagnanaratham,Ide Smets,Craig J. Smith,Peter Soors,Nikola Sprigg,Maximilian Spruegel,David Stark,Susanne Steinert,Sebastian Stösser,Markus Stuermlinger,Bart Swinnen,Ruben Tamazyan,Jose Tembl,Mikel Terceno Izaga,Emmanuel Touzé,Thomas Truelsen,Guillaume Turc,Gaetane Turine,Serdar Tütüncü,Pippa Tyrell,Xavier Ustrell,Wilfried Vadot,Anne Evelyne Vallet,Pauline Vallet,Lucie A. van den Berg,Sophie A. van den Berg,Cecile van Eendenburg,Robbert Jan Van Hooff,Isabelle van Sloten,Peter Vanacker,Evelien Vancaester,Patrick Vanderdonckt,Yves Vandermeeren,Frederik Vanhee,Roland Veltkamp,Karsten Vestergaard,Alain Viguier,Dolores Vilas,Kersten Villringer,Dieke Voget,Jörg von Schrader,Paul von Weitzel,Elisabeth Warburton,Claudia Weber,Jörg Weber,Karl Wegscheider,Mirko Wegscheider,Christian Weimar,Karin Weinstich,Christopher Weise,Gesa Weise,Chris Willems,Klemens Winder,Matthias Wittayer,Marc Wolf,Martin Wolf,Valerie Wolff,Christian Wollboldt,Frank A. Wollenweber,Anke Wouters,Bertrand Yalo,Marion Yger,Nadia Younan,Laetita Yperzeele,Vesna Zegarac,Pia Zeiner,Ulf Ziemann,Thomas P. Zonneveld,Mathieu Zuber,Tsugio Akutsu,Junya Aoki,Shuji Arakawa,Ryosuke Doijiri,Yusuke Egashira,Yukiko Enomoto,Eisuke Furui,Konosuke Furuta,Seiji Gotoh,Toshimitsu Hamasaki,Yasuhiro Hasegawa,Teryuki Hirano,Kazunari Homma,Masahiko Ichijyo,Toshihiro Ide,Shuichi Igarashi,Yasuyuki Iguchi,Masafumi Ihara,Hajime Ikenouchi,Tsuyoshi Inoue,Ryo Itabashi,Yasuhiro Ito,Toru Iwama,Kenji Kamiyama,Shoko Kamiyoshi,Haruka Kanai,Yasuhisa Kanematsu,Takao Kanzawa,Kazumi Kimura,Jiro Kitayama,Takanari Kitazono,Rei Kondo,Kohsuke Kudo,Masayoshi Kusumi,Ken Kuwahara,Shoji Matsumoto,Hideki Matsuoka,Ban Mihara,Kazuo Minematsu,Ken Miura,Naomi Morita,Wataru Mouri,Kayo Murata,Yoshinari Nagakane,Taizen Nakase,Hiromi Ohara,Nobuyuki Ohara,Hideyuki Ohnishi,Hajime Ohta,Masafumi Ohtaki,Ryo Ohtani,Toshiho Ohtsuki,Hideo Ohyama,Takashi Okada,Yasushi Okada,Masato Osaki,Nobuyuki Sakai,Yoshiki Sanbongi,Naoshi Sasaki,Makoto Sasaki,Shoichiro Sato,Kenta Seki,Wataru Shimizu,Yoshiaki Shiokawa,Takashi Sozu,Junichiro Suzuki,Rieko Suzuki,Yasushi Takagi,Shunya Takizawa,Norio Tanahashi,Eijiro Tanaka,Ryota Tanaka,Yohei Tateishi,Tomoaki Terada,Tadashi Terasaki,Kenichi Todo,Azusa Tokunaga,Akira Tsujino,Toshihiro Ueda,Yoshikazu Uesaka,Mihoko Uotani,Takao Urabe,Masao Watanabe,Yoshiki Yagita,Yusuke Yakushiji,Keizo Yasui,Toshiro Yonehara,Shinichi Yoshimura,Karoliina Aarnio,Fana Alemseged,Craig S. Anderson,T. Ang,M. L. Archer,John Attia,Peter L. Bailey,Anna H. Balabanski,Alan Barber,P A Barber,Julie Bernhardt,Andrew Bivard,Deborah Blacker,C. F. Bladin,Amy Brodtmann,Dominique A Cadilhac,Leeanne M. Carey,Sherisse Celestino,L. Chan,W. H. Chang,A. ChangI,C. H. Chen,C. I. Chen,H. F. Chen,T. C. Chen,W. H. Chen,Y. Y. Chen,C. A. Cheng,E. Cheong,Y. W. Chiou,Philip M.C. Choi,H. J. Chu,C. S. Chuang,T. C. Chung,L. Churilov,Benjamin Clissold,Alan Connelly,Skye Coote,Bronwyn Coulton,Elise Cowley,Jennifer Cranefield,Sami Curtze,Cate D'Este,S. M. Davis,Susan Day,Patricia Desmond,H Dewey,C. Ding,Roy Drew,S. Eirola,Deborah Field,Tanya Frost,Carlos Garcia-Esperon,K. George,Richard P. Gerraty,R. Grimley,Y. C. Guo,Graeme J. Hankey,John T Harvey,S. C. Ho,K. Hogan,David W. Howells,P. M. Hsiao,Chung Hsu,C. T. Hsu,C. S. Hsu,J. P. Hsu,Y. D. Hsu,Y. T. Hsu,C. J. Hu,C. C. Huang,H. Y. Huang,M. Y. Huang,S. C. Huang,W. S. Huang,David C. Jackson,J. S. Jeng,S. K. Jiang,Lara Kaauwai,O. Kasari,J. King,M. Koivu,John Kolbe,Martin Krause,C. W. Kuan,W. L. Kung,C. Kyndt,C. L. Lau,A. Lee,Cheryl Yi-Pin Lee,J. T. Lee,Y. Lee,Y. C. Lee,Christopher Levi,C. R. Levi,L. M. Lien,J. C. Lim,C. C. Lin,C. H. Lin,C. M. Lin,D. Lin,C. H. Liu,J. Liu,Y. C. Lo,P. S. Loh,Essie Low,C. H. Lu,C. J. Lu,M. K. Lu,J. Ly,Lance Macaulay,Richard Macdonnell,Elizabeth Mackey,Malcolm R. Macleod,Jeyaledchumy Mahadevan,Vanessa Maxwell,Rachael McCoy,Amy A. McDonald,S. McModie,Atte Meretoja,Shiva Raj Mishra,Peter Mitchell,Ferdinand Miteff,A. Moore,Claire Muller,F. Ng,F. C. Ng,J. L. Ng,W. O'Brian,Victoria E O'Collins,Thomas J Oxley,Sandy Patel,G. S. Peng,Lauren Pesavento,T. Phan,Edrich Rodrigues,Z. Ross,Arman Sabet,M. Sallaberger,Patrick Salvaris,Darshan Shah,Gagan Sharma,Gerli Sibolt,Marion Simpson,Shaloo Singhal,Barry Snow,Neil J. Spratt,Richard J Stark,Jonathon Sturm,M. C. Sun,Y. Sun,P. S. Sung,Y. F. Sung,M. Suzuki,M. Tan,S. C. Tang,Turgut Tatlisumak,V. Thijs,V. Thijs,Marjaana Tiainen,C. H. Tsai,C. K. Tsai,C. L. Tsai,H. T. Tsai,L. K. Tsai,C. H. Tseng,L. T. Tseng,Jessica Tsoleridis,H. Tu,H. T.H. Tu,Wilson Vallat,J. Virta,W. C. Wang,Y. T. Wang,Michael J. Waters,Louise Weir,Tissa Wijeratne,Cylie Williams,William Wilson,A. A. Wong,K. Wong,T. Y. Wu,Y. H. Wu,B. Yan,F. C. Yang,Y. W. Yang,N. Yassi,N. Yassi,H. L. Yeh,J. H. Yeh,S. J. Yeh,C. H. Yen,D. Young,C. L. Ysai,W. W. Zhang,Henry Zhao,L. Zhao,Katharina Althaus-Knaurer,Jörg Berrouschot,Erich Bluhmki,Paolo Bovi,Gilles Chatellier,Lynda Cove,Stephen M. Davis,A. Dixit,Christina Ehrenkrona,Christoph C. Eschenfelder,Marc Fatar,Juan F. Arenillas,Franz Gruber,Lalit Kala,Peter Kapeller,Markku Kaste,Christof Kessler,Martin Köhrmann,Rico Laage,Kennedy R. Lees,Alain Luna Rodriguez,Jean-Louis Mas,Robert Mikulik,Carlos A. Molina,Girish Muddegowda,Kurt Niederkorn,Xavier Nuñez,Joaquín Serena,Jan Sobesky,Thorsten Steiner,Ann Sofie Svenson,Rüdiger von Kummer,Joanna M. Wardlaw,Rebecca A. Betensky,Gregoire Boulouis,Raphael A. Carandang,William A. Copen,Pedro Cougo,Shawna Cutting,Kendra Drake,Andria L. Ford,John Hallenbeck,Gordon J. Harris,Robert Hoesch,Amie Hsia,Carlos S. Kase,Lawrence L. Latour,Michael H. Lev,Alona Muzikansky,Nandakumar Nagaraja,Eric Searls,Sidney Starkman,Albert J Yoo,Ramin Zand +775 more
TL;DR: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care despite an increased risk of symptomatic intracranial haemorrhage.
Journal ArticleDOI
Perfusion quantification using Gaussian process deconvolution.
Irene Klærke Andersen,Irene Klærke Andersen,A. Szymkowiak,Carl Edward Rasmussen,Lars G. Hanson,Jacob Marstrand,Henrik Larsson,Lars Kai Hansen +7 more
TL;DR: In this work, a method using the Gaussian process for deconvolution (GPD) is proposed, and it is shown that GPD is comparable to SVD with a variable optimized threshold when determining the maximum of the IRF, which is directly related to the perfusion.