G
G. M. Besser
Researcher at St Bartholomew's Hospital
Publications - 286
Citations - 15897
G. M. Besser is an academic researcher from St Bartholomew's Hospital. The author has contributed to research in topics: Prolactin & Acromegaly. The author has an hindex of 71, co-authored 286 publications receiving 15583 citations. Previous affiliations of G. M. Besser include University of Turin & Kwong Wah Hospital.
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Journal ArticleDOI
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome
John D. Carpten,Christiane M. Robbins,Andrea Villablanca,Lars Forsberg,Silvano Presciuttini,Joan E. Bailey-Wilson,William F. Simonds,E. Gillanders,A.M. Kennedy,Jindong Chen,Sunita K. Agarwal,Raman Sood,Mary Pat Jones,Tracy Moses,C. Haven,David Petillo,P.D. Leotlela,Brian Harding,David Cameron,Anna A.J. Pannett,Anders Höög,H. Heath,Laura James-Newton,Bruce G. Robinson,R.J. Zarbo,Branca M. Cavaco,Wassif S. Wassif,N.D. Perrier,I.B. Rosen,Ulf Kristoffersson,Peter D. Turnpenny,Lars-Ove Farnebo,G. M. Besser,Charles E. Jackson,Hans Morreau,J.M. Trent,Rajesh V. Thakker,Stephen J. Marx,Bin Tean Teh,Catharina Larsson,Maurine R. Hobbs +40 more
TL;DR: The findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT–JT and in development of some sporadic parathyroid tumors.
Journal ArticleDOI
Clinical studies of multiple endocrine neoplasia type 1 (MEN1)
D Trump,B. Farren,C Wooding,J T Pang,G. M. Besser,K D Buchanan,C.R. Edwards,D A Heath,Charles E. Jackson,S. Jansen,K. Lips,John P. Monson,Domhnall J O'Halloran,Julian R. Sampson,Stephen M Shalet,M.H. Wheeler,A. Zink,Rajesh V. Thakker +17 more
TL;DR: Investigation of multiple endocrine neoplasia type 1 patients found that parathyroid tumours were the first manifestation of MEN1 in 87% of patients, and amongst the pituitary and pancreatic tumours, somatotrophinomas and gastrinomas were more common in patients above the age of 40 years, whilst insulinomas occurred more frequently in patients below the ageof 40 years.
Journal ArticleDOI
Characterization of Mutations in Patients with Multiple Endocrine Neoplasia Type 1
J. H. D. Bassett,Simon A. Forbes,Anna A.J. Pannett,S E Lloyd,Paul T. Christie,C Wooding,Brian Harding,G. M. Besser,C.R. Edwards,John P. Monson,Julian R. Sampson,John A.H. Wass,M.H. Wheeler,Rajesh V. Thakker +13 more
TL;DR: The results provide the basis for a molecular-genetic screening approach that will supplement the clinical evaluation and genetic counseling of members of MEN1 families and SSCP was found to be a sensitive and specific mutational screening method that detected >85% of the mutations.
Journal ArticleDOI
INCREASED β-ENDORPHIN BUT NOT MET-ENKEPHALIN LEVELS IN HUMAN CEREBROSPINAL FLUID AFTER ACUPUNCTURE FOR RECURRENT PAIN
Vicky Clement-Jones,Vicky Clement-Jones,Susan Tomlin,Susan Tomlin,LesleyH. Rees,LesleyH. Rees,Lorraine McLoughlin,Lorraine McLoughlin,G. M. Besser,G. M. Besser,H.L. Wen,H.L. Wen +11 more
TL;DR: The results suggest that the analgesia observed after electroacupuncture in patients with recurrent pain may be mediated by the release into the CSF of the endogenous opiate, beta-endorphin.
Journal ArticleDOI
Hormonal and metabolic responses to an enkephalin analogue in normal man
W. A. Stubbs,Anthony K. P. Jones,C. R. W. Edwards,G. Delitala,W. J. Jeffcoate,Sally J. Ratter,G. M. Besser,S.R. Bloom,K. G. M. M. Alberti +8 more
TL;DR: An enkephalin analogue given intravenously to normal subjects raised serum prolactin and growth-hormone levels but lowered serum levels of luteinising hormone, follicle-stimulating hormone, cortisol, and corticotrophin.