Journal ArticleDOI
A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.
Anil Potti,Sayan Mukherjee,Rebecca P. Petersen,Holly K. Dressman,Andrea Bild,Jason I. Koontz,Robert A. Kratzke,Mark A. Watson,Michael J. Kelley,Geoffrey S. Ginsburg,Mike West,David H. Harpole,Joseph R. Nevins +12 more
TLDR
The lung metagene model provides a potential mechanism to refine the estimation of a patient's risk of disease recurrence and, in principle, to alter decisions regarding the use of adjuvant chemotherapy in early-stage NSCLC.Abstract:
Background Clinical trials have indicated a benefit of adjuvant chemotherapy for patients with stage IB, II, or IIIA — but not stage IA — non–small-cell lung cancer (NSCLC). This classification scheme is probably an imprecise predictor of the prognosis of an individual patient. Indeed, approximately 25 percent of patients with stage IA disease have a recurrence after surgery, suggesting the need to identify patients in this subgroup for more effective therapy. Methods We identified gene-expression profiles that predicted the risk of recurrence in a cohort of 89 patients with early-stage NSCLC (the lung metagene model). We evaluated the predictor in two independent groups of 25 patients from the American College of Surgeons Oncology Group (ACOSOG) Z0030 study and 84 patients from the Cancer and Leukemia Group B (CALGB) 9761 study. Results The lung metagene model predicted recurrence for individual patients significantly better than did clinical prognostic factors and was consistent across all early stages ...read more
Citations
More filters
Journal ArticleDOI
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
William D. Travis,Elisabeth Brambilla,Masayuki Noguchi,Andrew G. Nicholson,Kim R. Geisinger,Yasushi Yatabe,David G. Beer,Charles A. Powell,Gregory J. Riely,Paul Van Schil,Kavita Garg,John H. M. Austin,Hisao Asamura,Valerie W. Rusch,Fred R. Hirsch,Giorgio V. Scagliotti,Tetsuya Mitsudomi,Rudolf M. Huber,Yuichi Ishikawa,James R. Jett,Montserrat Sanchez-Cespedes,Jean-Paul Sculier,Takashi Takahashi,Masahiro Tsuboi,Johan Vansteenkiste,Ignacio I. Wistuba,Pan-Chyr Yang,Denise R. Aberle,Christian Brambilla,Douglas B. Flieder,Wilbur A. Franklin,Adi F. Gazdar,Michael K. Gould,Philip S. Hasleton,Douglas W. Henderson,Bruce E. Johnson,David A Johnson,Keith M. Kerr,Keiko Kuriyama,Jin Soo Lee,Vincent A. Miller,Iver Petersen,Victor L. Roggli,Rafael Rosell,Nagahiro Saijo,Erik Thunnissen,M. Tsao,David Yankelewitz +47 more
TL;DR: This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies.
Journal ArticleDOI
Molecular origins of cancer: Lung cancer
TL;DR: From the Departments of Thoracic/Head and Neck Medical Oncology and Clinical Cancer Prevention, University of Texas M.D. Anderson Cancer Center, Houston.
Journal ArticleDOI
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study.
Kerby Shedden,Jeremy M. G. Taylor,Steven A. Enkemann,Ming-Sound Tsao,Timothy J. Yeatman,William L. Gerald,Steven A. Eschrich,Igor Jurisica,Thomas J. Giordano,David E. Misek,Andrew C. Chang,Chang-Qi Zhu,Daniel Strumpf,Samir M. Hanash,Frances A. Shepherd,Keyue Ding,Lesley Seymour,Katsuhiko Naoki,Nathan A. Pennell,Barbara A. Weir,Roeland Verhaak,Christine Ladd-Acosta,Todd R. Golub,Michael Gruidl,Anupama Sharma,Janos Szoke,Maureen F. Zakowski,Valerie W. Rusch,Mark G. Kris,Agnes Viale,Noriko Motoi,William D. Travis,Barbara A. Conley,Venkatraman E. Seshan,Matthew Meyerson,Matthew Meyerson,Rork Kuick,Kevin K. Dobbin,Tracy Lively,James W. Jacobson,David G. Beer +40 more
TL;DR: A large, training–testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas, providing the largest available set of microarray data with extensive pathological and clinical annotation for lungAdenocARCinomas.
Journal ArticleDOI
Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer
Zhibin Hu,Xi Chen,Yang Zhao,Tian Tian,Guangfu Jin,Yongqian Shu,Yijiang Chen,Lin Xu,Ke Zen,Chen-Yu Zhang,Hongbing Shen +10 more
TL;DR: The four-miRNA signature from the serum may serve as a noninvasive predictor for the overall survival of NSCLC.
Journal ArticleDOI
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer
Sung-Liang Yu,Hsuan-Yu Chen,Hsuan-Yu Chen,Gee-Chen Chang,Chih Yi Chen,Huei-Wen Chen,Sher Singh,Chiou Ling Cheng,Chong-Jen Yu,Yung Chie Lee,Han Shiang Chen,Te Jen Su,Te Jen Su,Ching Cheng Chiang,Li Hn,Qi Sheng Hong,Hsin Yuan Su,Chun Chieh Chen,Wan Jiun Chen,Liu Cc,Wing Kai Chan,Wei J. Chen,Ker-Chau Li,Ker-Chau Li,Jeremy J.W. Chen,Jeremy J.W. Chen,Pan-Chyr Yang,Pan-Chyr Yang +27 more
TL;DR: Using real-time RT-PCR, the authors obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets, and used Cox regression and risk-score analysis to identify a five microRNA signatures for the prediction of treatment outcome.
References
More filters
Journal ArticleDOI
Revisions in the International System for Staging Lung Cancer
TL;DR: Analysis of a collected database representing all clinical, surgical-pathologic, and follow-up information for 5,319 patients treated for primary lung cancer confirmed the validity of the TNM and stage grouping classification schema.
Journal ArticleDOI
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara,Natasha J. Caplen,Elise D. Bowman,Masahiro Seike,Kensuke Kumamoto,Ming Yi,Robert M. Stephens,Aikou Okamoto,Jun Yokota,Tadao Tanaka,George A. Calin,Chang Gong Liu,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
Journal ArticleDOI
Statistical Modeling: The Two Cultures (with comments and a rejoinder by the author)
TL;DR: Algorithmic models have been widely used in fields outside statistics as discussed by the authors, both in theory and practice, and can be used both on large complex data sets and as a more accurate and informative alternative to data modeling on smaller data sets.
Journal ArticleDOI
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
Arindam Bhattacharjee,William G. Richards,Jane Staunton,Cheng Li,Stefano Monti,Priya Vasa,Christine Ladd,Javad Beheshti,Raphael Bueno,Michael A. Gillette,Massimo Loda,Griffin M. Weber,Eugene J. Mark,Eric S. Lander,Wing Hung Wong,Bruce E. Johnson,Todd R. Golub,Todd R. Golub,David J. Sugarbaker,Matthew Meyerson +19 more
TL;DR: A molecular taxonomy of lung carcinoma is generated and results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients.
Journal ArticleDOI
Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer.
Rodrigo Arriagada,Bengt Bergman,Ariane Dunant,Le Chevalier T,J.P. Pignon,Johan Vansteenkiste +5 more
TL;DR: Cisplatin-based adjuvant chemotherapy improves survival among patients with completely resected non-small-cell lung cancer and had a significantly higher survival rate than those assigned to observation.
Related Papers (5)
Gene-expression profiles predict survival of patients with lung adenocarcinoma
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
Arindam Bhattacharjee,William G. Richards,Jane Staunton,Cheng Li,Stefano Monti,Priya Vasa,Christine Ladd,Javad Beheshti,Raphael Bueno,Michael A. Gillette,Massimo Loda,Griffin M. Weber,Eugene J. Mark,Eric S. Lander,Wing Hung Wong,Bruce E. Johnson,Todd R. Golub,Todd R. Golub,David J. Sugarbaker,Matthew Meyerson +19 more
Vinorelbine plus Cisplatin vs. Observation in Resected Non–Small-Cell Lung Cancer
Timothy Winton,Robert B. Livingston,David H. Johnson,James R. Rigas,Michael R. Johnston,Charles Butts,Yvon Cormier,Glenwood D. Goss,Richard Inculet,Eric Vallières,Willard A Fry,Drew Bethune,Joseph Ayoub,Keyue Ding,Lesley Seymour,Barbara Graham,Ming-Sound Tsao,David R. Gandara,Kenneth A. Kesler,Todd L. Demmy,Frances A. Shepherd +20 more