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Alexandros Marios Sofias
Researcher at RWTH Aachen University
Publications - 25
Citations - 845
Alexandros Marios Sofias is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Drug delivery & Medicine. The author has an hindex of 10, co-authored 18 publications receiving 408 citations. Previous affiliations of Alexandros Marios Sofias include Icahn School of Medicine at Mount Sinai & University of Toronto.
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Journal ArticleDOI
The battle of “nano” paclitaxel
TL;DR: A comprehensive analysis of these new formulations of PTX demonstrates that they are largely clinically equivalent to Abraxane, indicating significant room for development of a superior nano‐formulation of paclitaxel.
Journal ArticleDOI
Dexamethasone nanomedicines for COVID-19.
Twan Lammers,Twan Lammers,Twan Lammers,Alexandros Marios Sofias,Roy van der Meel,Raymond M. Schiffelers,Gert Storm,Gert Storm,Gert Storm,Frank Tacke,Steffen Koschmieder,Tim H. Brümmendorf,Fabian Kiessling,Josbert M. Metselaar +13 more
TL;DR: Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells and by exploiting its anti-fibrotic effects.
Journal ArticleDOI
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.
Bram Priem,Mandy M. T. van Leent,Mandy M. T. van Leent,Abraham J. P. Teunissen,Alexandros Marios Sofias,Alexandros Marios Sofias,Vera P. Mourits,Lisa Willemsen,Emma D. Klein,Roderick S. Oosterwijk,Anu E. Meerwaldt,Anu E. Meerwaldt,Jazz Munitz,Geoffrey Prévot,Anna Vera D Verschuur,Sheqouia A. Nauta,Esther M. van Leeuwen,Elizabeth L. Fisher,Karen A.M. de Jong,Yiming Zhao,Yohana C. Toner,Georgios Soultanidis,Claudia Calcagno,Paul H. H. Bomans,Heiner Friedrich,Nico A. J. M. Sommerdijk,Thomas Reiner,Thomas Reiner,Raphaël Duivenvoorden,Raphaël Duivenvoorden,Eva Zupančič,Julie Di Martino,Ewelina Kluza,Mohammad Rashidian,Hidde L. Ploegh,Rick M. Dijkhuizen,Sjoerd Hak,Carlos Pérez-Medina,Carlos Pérez-Medina,Jose Javier Bravo-Cordero,Menno P.J. de Winther,Leo A. B. Joosten,Leo A. B. Joosten,Andrea van Elsas,Zahi A. Fayad,Alexander Rialdi,Denis Torre,Ernesto Guccione,Jordi Ochando,Jordi Ochando,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Arjan W. Griffioen,Willem J. M. Mulder +54 more
TL;DR: It is shown that rationally designed nanobiologics can promote trained immunity and elicit a durable anti-tumor response either as a monotherapy or in combination with checkpoint inhibitor drugs.
Journal ArticleDOI
Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies.
Pol Escudé Martinez de Castilla,Lingjun Tong,Chenyuan Huang,Alexandros Marios Sofias,Giorgia Pastorin,Xiaoyuan Chen,Gert Storm,Raymond M. Schiffelers,Jiong-Wei Wang +8 more
TL;DR: In this paper, extracellular vesicles (EVs) have emerged as an attractive drug delivery system and the authors assess their pre-clinical applications, in the form of a systematic review.
Journal ArticleDOI
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking.
Alexandros Marios Sofias,Alexandros Marios Sofias,Alexandros Marios Sofias,Yohana C. Toner,Anu E. Meerwaldt,Anu E. Meerwaldt,Mandy M. T. van Leent,Mandy M. T. van Leent,Georgios Soultanidis,Mattijs Elschot,Haruki Gonai,Kristin Grendstad,Åsmund Flobak,Ulrike Neckmann,Camilla Wolowczyk,Elizabeth L. Fisher,Thomas Reiner,Thomas Reiner,Catharina de Lange Davies,Geir Bjørkøy,Abraham J. P. Teunissen,Jordi Ochando,Jordi Ochando,Carlos Pérez-Medina,Carlos Pérez-Medina,Willem J. M. Mulder,Willem J. M. Mulder,Willem J. M. Mulder,Sjoerd Hak,Sjoerd Hak +29 more
TL;DR: It is observed that ligand-mediated accumulation in cancerous lesions is multifaceted and identified “NP hitchhiking” with phagocytes to contribute considerably to this intricate process.