Girish Mallya Udupi

TL;DR: These findings show how targeting TAMs can effectively overcome therapeutic resistance mediated by TICs and improve chemotherapeutic efficacy, inhibits metastasis, and increases antitumor T-cell responses.

TL;DR: A transcriptional signaling network in which the EMT transcription factor ZEB2 regulates MITF levels to control melanocyte differentiation is identified and is relevant for human melanomagenesis as loss of Zeb2 expression is associated with reduced patient survival.

TL;DR: Evaluated CDK7 expression and Mechanistic investigations revealed that the survival of MDA-MB-231 TNBC cells relied heavily on the BCL-2/BCL-XL signaling axes in cells, and synergized in producing growth inhibition and apoptosis of human T NBC cells.

TL;DR: It is suggested that a cardiac PET strategy may represent a rational approach to non-invasively monitor metabolic pathway remodeling following sunitinib treatment, indicating a fundamental energy crisis resulting in compromised myocardial energy metabolism and function.

TL;DR: This study provides a generalizable framework to optimize the development of network-based prognostic assays and, ultimately, to facilitate their integration in the routine clinical workflow.