G
Graham Rose
Researcher at Public Health England
Publications - 27
Citations - 2387
Graham Rose is an academic researcher from Public Health England. The author has contributed to research in topics: Mycobacterium tuberculosis & Genome. The author has an hindex of 14, co-authored 26 publications receiving 2170 citations. Previous affiliations of Graham Rose include Great Ormond Street Hospital & National Institute for Medical Research.
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Journal ArticleDOI
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
Richard A. Stabler,Miao-Xia He,Lisa F. Dawson,Melissa J. Martin,Esmeralda Valiente,Craig Corton,Trevor D. Lawley,Mohammed Sebaihia,Michael A. Quail,Graham Rose,Dale N. Gerding,Maryse Gibert,Michel R. Popoff,Julian Parkhill,Gordon Dougan,Brendan W. Wren +15 more
TL;DR: This study provides genetic markers for the identification of 027 strains and offers a unique opportunity to explain the recent emergence of a hypervirulent bacterium.
Journal ArticleDOI
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.
Iñaki Comas,Sonia Borrell,Sonia Borrell,Andreas Roetzer,Graham Rose,Bijaya Malla,Bijaya Malla,Midori Kato-Maeda,James E. Galagan,James E. Galagan,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +12 more
TL;DR: These findings support a role for compensatory evolution in the global epidemics of MDR TB and show that M. tuberculosis strains harboring these compensatory mutations showed a high competitive fitness in vitro and were associated with high fitness in vivo.
Journal ArticleDOI
Evolutionary dynamics of Clostridium difficile over short and long time scales
Miao He,Mohammed Sebaihia,Trevor D. Lawley,Richard A. Stabler,Lisa F. Dawson,Melissa J. Martin,Kathryn E. Holt,Helena M. B. Seth-Smith,Michael A. Quail,Richard Rance,Karen Brooks,Carol Churcher,David Harris,Stephen D. Bentley,Christine Burrows,Louise Clark,Craig Corton,Vicky Murray,Graham Rose,Scott Thurston,Andries J. van Tonder,Danielle Walker,Brendan W. Wren,Gordon Dougan,Julian Parkhill +24 more
TL;DR: Phylogenetic analysis demonstrates C. difficile is a genetically diverse species, which has evolved within the last 1.1–85 million years, and the disease-causing isolates have arisen from multiple lineages, suggesting that virulence evolved independently in the highly epidemic lineages.
Journal ArticleDOI
Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis
Teresa Cortes,Olga T. Schubert,Graham Rose,Kristine B. Arnvig,Iñaki Comas,Ruedi Aebersold,Douglas B. Young,Douglas B. Young +7 more
TL;DR: Genes encoding proteins with active growth functions were markedly depleted from the leaderless transcriptome, and there was a significant increase in the overall representation of leaderless mRNAs in a starvation model of growth arrest.
Journal ArticleDOI
Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.
Kristine B. Arnvig,Iñaki Comas,Nicholas R. Thomson,Joanna Houghton,Helena I. Boshoff,Nicholas J. Croucher,Graham Rose,Tim Perkins,Julian Parkhill,Gordon Dougan,Douglas B. Young +10 more
TL;DR: RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5’ and 3’ untranslated regions, antisense transcripts, and intergenic small RNA (sRNA) molecules.