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Andries J. van Tonder
Researcher at University of Cambridge
Publications - 45
Citations - 1822
Andries J. van Tonder is an academic researcher from University of Cambridge. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 17, co-authored 37 publications receiving 1382 citations. Previous affiliations of Andries J. van Tonder include Wellcome Trust Sanger Institute & University of Oxford.
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Journal ArticleDOI
Evolutionary dynamics of Clostridium difficile over short and long time scales
Miao He,Mohammed Sebaihia,Trevor D. Lawley,Richard A. Stabler,Lisa F. Dawson,Melissa J. Martin,Kathryn E. Holt,Helena M. B. Seth-Smith,Michael A. Quail,Richard Rance,Karen Brooks,Carol Churcher,David Harris,Stephen D. Bentley,Christine Burrows,Louise Clark,Craig Corton,Vicky Murray,Graham Rose,Scott Thurston,Andries J. van Tonder,Danielle Walker,Brendan W. Wren,Gordon Dougan,Julian Parkhill +24 more
TL;DR: Phylogenetic analysis demonstrates C. difficile is a genetically diverse species, which has evolved within the last 1.1–85 million years, and the disease-causing isolates have arisen from multiple lineages, suggesting that virulence evolved independently in the highly epidemic lineages.
Journal ArticleDOI
A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus
Feroze Ganaie,Jamil S. Saad,Lesley McGee,Andries J. van Tonder,Stephen D. Bentley,Stephanie W. Lo,Rebecca A. Gladstone,Paul Turner,Paul Turner,Jeremy D. Keenan,Robert F. Breiman,Moon H. Nahm +11 more
TL;DR: A new and the 100th capsule type, named serotype 10D, is described, by determining its unique chemical structure and biosynthetic roles of all capsule synthesis locus (cps) genes, which provides compelling evidence for a recent interspecies genetic transfer from oral streptococcus to pneumococcus.
Journal ArticleDOI
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
Andrew P. Jackson,Andrew Berry,Martin Aslett,Harriet C. Allison,Peter Burton,Jana Vavrova-Anderson,Robert W. Brown,Hilary P. Browne,Nicola Corton,Heidi Hauser,John Gamble,Ruth Gilderthorp,Lucio Marcello,Jacqueline A. McQuillan,Thomas D. Otto,Michael A. Quail,Mandy Sanders,Andries J. van Tonder,Michael L. Ginger,Mark C. Field,J. David Barry,Christiane Hertz-Fowler,Christiane Hertz-Fowler,Matthew Berriman +23 more
TL;DR: How past VSG evolution indirectly determines the ability of contemporary parasites to generate novel variant antigens through recombination is demonstrated and suggest that the current model for antigenic variation in Trypanosoma brucei is only one means by which these parasites maintain chronic infections.
Journal ArticleDOI
Comparative Genomics of Vancomycin-Resistant Staphylococcus aureus Strains and Their Positions within the Clade Most Commonly Associated with Methicillin-Resistant S. aureus Hospital-Acquired Infection in the United States
Veronica N. Kos,Veronica N. Kos,Christopher A. Desjardins,Allison D. Griggs,Gustavo C. Cerqueira,Andries J. van Tonder,Matthew T. G. Holden,Paul A. Godfrey,Kelli L. Palmer,Kip L Bodi,Emmanuel F. Mongodin,Jennifer R. Wortman,Michael Feldgarden,Trevor D. Lawley,Steven R. Gill,Brian J. Haas,Bruce W. Birren,Michael S. Gilmore,Michael S. Gilmore +18 more
TL;DR: To understand the nature of VRSA strains, high-quality draft genome sequences were determined and nucleotide sequences of the genomes of all available VRSA were examined, finding a constellation of traits that appears to be optimized for proliferation in precisely the types of polymicrobic infection where transfer could occur.
Journal ArticleDOI
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study.
Stephanie W. Lo,Rebecca A. Gladstone,Andries J. van Tonder,John A. Lees,Mignon du Plessis,Rachel Benisty,Noga Givon-Lavi,Paulina A. Hawkins,Jennifer E. Cornick,Brenda Kwambana-Adams,Brenda Kwambana-Adams,Pierra Y. Law,Pak-Leung Ho,Martin Antonio,Dean Everett,Ron Dagan,Anne von Gottberg,Keith P. Klugman,Lesley McGee,Robert F. Breiman,Stephen D. Bentley,Abdullah Brooks,Alejandra Corso,Alexander Davydov,Alison J. Maguire,Andrew J. Pollard,Anmol M. Kiran,Anna Skoczynska,Benild Moiane,Bernard Beall,Betuel Sigaúque,David M. Aanensen,Deborah Lehmann,Diego Faccone,Ebenezer Foster-Nyarko,Ebrima Bojang,Ekaterina Egorova,Elena Voropaeva,Eric Sampane-Donkor,Ewa Sadowy,Godfrey Bigogo,Helio Mucavele,Houria Belabbès,Idrissa Diawara,Jennifer C. Moïsi,Jennifer R. Verani,Jeremy D. Keenan,Jyothish N Nair Thulasee Bhai,Kedibone M. Ndlangisa,Khalid Zerouali,K L Ravikumar,Leonid Titov,Linda de Gouveia,Maaike Alaerts,Margaret Ip,Maria Cristina de Cunto Brandileone,Hasanuzzaman,Metka Paragi,Michele Nurse-Lucas,Mushal Ali,Naima Elmdaghri,Nicholas J. Croucher,Nicole Wolter,Nurit Porat,Ozgen Koseoglu Eser,Patrick Eberechi Akpaka,Paul Turner,Paula Gagetti,Peggy-Estelle Tientcheu,Philip E. Carter,Rafal Mostowy,Rama Kandasamy,Rebecca Ford,Rebecca Henderson,Roly Malaker,Sadia Shakoor,Samanta Cristine Grassi Almeida,Samir K. Saha,Sanjay Doiphode,Shabir A. Madhi,Shamala Devi Sekaran,Somporn Srifuengfung,Stephen K. Obaro,Stuart C. Clarke,Susan A. Nzenze,Tamara Kastrin,Theresa J. Ochoa,Veeraraghavan Balaji,Waleria Hryniewicz,Yulia Urban +89 more
TL;DR: In this paper, a whole-genome sequenced 3233 invasive pneumococcal disease isolates from laboratory-based surveillance programs in Hong Kong (n=78), Israel, South Africa, Malawi, Nigeria, The Gambia, and USA were collected from children younger than 3 years.