Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
Eek Joong Park,Jun Hee Lee,Guann-Yi Yu,Guobin He,Syed Raza Ali,Ryan G. Holzer,Christoph H. Österreicher,Hiroyuki Takahashi,Michael Karin +8 more
TLDR
It is demonstrated that either dietary or genetic obesity is a potent bona fide liver tumor promoter in mice and obesity-promoted HCC development was dependent on enhanced production of the tumor-promoting cytokines IL-6 and TNF, which cause hepatic inflammation and activation of the oncogenic transcription factor STAT3.About:
This article is published in Cell.The article was published on 2010-01-22 and is currently open access. It has received 1537 citations till now. The article focuses on the topics: Chronic inflammatory response & Liver cancer.read more
Citations
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Diabetes and Cancer: A consensus report
Edward Giovannucci,David M. Harlan,Michael C. Archer,Richard M. Bergenstal,Susan M. Gapstur,Laurel A. Habel,Michael Pollak,Judith G. Regensteiner,Douglas Yee +8 more
TL;DR: A consensus statement of experts assembled jointly by the American Diabetes Association and the American Cancer Society reviews the state of science concerning the association between diabetes and cancer incidence or prognosis and whether diabetes treatments influence risk of cancer or cancer prognosis.
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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Shin Yoshimoto,Tze Mun Loo,Tze Mun Loo,Koji Atarashi,Hiroaki Kanda,Seidai Sato,Seiichi Oyadomari,Yoichiro Iwakura,Kenshiro Oshima,Hidetoshi Morita,Masahira Hattori,Kenya Honda,Yuichi Ishikawa,Eiji Hara,Naoko Ohtani +14 more
TL;DR: It is shown that senescence-associated secretory phenotype (SASP) has crucial roles in promoting obesity-associated hepatocellular carcinoma (HCC) development in mice, and a similar pathway may contribute to at least certain aspects of obesity- associated HCC development in humans as well.
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
References
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TL;DR: A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.
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