Gunnar Dittmar

TL;DR: Using a quantitative model, the first genome-scale prediction of synthesis rates of mRNAs and proteins is obtained and it is found that the cellular abundance of proteins is predominantly controlled at the level of translation.

TL;DR: This study provides strong evidence for translation of circRNAs, revealing the existence of an unexplored layer of gene activity.

TL;DR: Senescence-associated stemness is an unexpected, cell-autonomous feature that exerts its detrimental, highly aggressive growth potential upon escape from cell-cycle blockade, and is enriched in relapse tumours.

TL;DR: It is shown that Rad23 binds proteasomes by directly interacting with the base subcomplex of the regulatory particle of the proteasome, and it is proposed that the LRR domain of Rpn1 may be positioned in the base to allow the cargo proteins carried by Rad23 to be presented to the proteAsomal ATPases for unfolding.

TL;DR: Data suggest a regulatory role for multiubiquitin chains that is reversible and does not function to target the acceptor protein for degradation, and the K63R mutant of ubiquitin displays defects in ribosomal function in vivo and in vitro, including a dramatic sensitivity to translational inhibitors.