H
Hal E. Broxmeyer
Researcher at Indiana University
Publications - 56
Citations - 12179
Hal E. Broxmeyer is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Bone marrow. The author has an hindex of 26, co-authored 56 publications receiving 11650 citations. Previous affiliations of Hal E. Broxmeyer include University of Texas Health Science Center at Houston & University of Washington.
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Journal ArticleDOI
Increased osteoclast development after estrogen loss: mediation by interleukin-6
Robert L. Jilka,Giao Hangoc,Giuseppe Girasole,Giovanni Passeri,Daniel C. Williams,John S. Abrams,Brendan F. Boyce,Hal E. Broxmeyer,Stavros C. Manolagas +8 more
TL;DR: Estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.
Journal ArticleDOI
Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells
Hal E. Broxmeyer,Gordon W. Douglas,Giao Hangoc,Scott Cooper,Judith Bard,Denis English,Margaret Arny,Lewis Thomas,Edward A. Boyse +8 more
TL;DR: It was determined that granulocyte-macrophage, erythroid, and multipotential progenitor cells remained functionally viable in cord blood untreated except for addition of anticoagulant for at least 3 days at 4 degrees C or 25 degrees C (room temperature), though not at 37 degrees C, implying that these cells could be satisfactorily studied and used or cryopreserved for therapy.
Journal ArticleDOI
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Hal E. Broxmeyer,Christie M. Orschell,D. Wade Clapp,Giao Hangoc,Scott Cooper,P. Artur Plett,W. Conrad Liles,Xiaxin Li,Barbara Graham-Evans,Timothy B. Campbell,Gary Calandra,Gary Bridger,David C. Dale,Edward F. Srour +13 more
TL;DR: Results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization.
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Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
Hugo Castro-Malaspina,Hugo Castro-Malaspina,Hugo Castro-Malaspina,Gene Resnick,Gene Resnick,Gene Resnick,Neena Kapoor,Neena Kapoor,Neena Kapoor,Paul A. Meyers,Paul A. Meyers,Paul A. Meyers,Dominick R. Chiarieri,Dominick R. Chiarieri,Dominick R. Chiarieri,Susan Mckenzie,Susan Mckenzie,Susan Mckenzie,Hal E. Broxmeyer,Hal E. Broxmeyer,Hal E. Broxmeyer,Malcolm A.S. Moore,Malcolm A.S. Moore,Malcolm A.S. Moore +23 more
TL;DR: Analysis of CFU-F proliferative status by the thymidine suicide technique indicated that this cell was noncycling in individuals with undisturbed bone marrow function and data support the conclusion that the colonies described in this study are of fibroblastic nature.
Journal ArticleDOI
A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
Gregory A. Taylor,Ester Carballo,David M. Lee,Wi S. Lai,Michael J. Thompson,Dhavalkumar D. Patel,Daniel I. Schenkman,Gary S. Gilkeson,Hal E. Broxmeyer,Barton F. Haynes,Perry J. Blackshear +10 more
TL;DR: Treatment of young TTP-deficient mice with antibodies to tumor necrosis factor alpha (TNF alpha) prevented the development of essentially all aspects of the phenotype, indicating a role for TTP in regulating TNF alpha synthesis, secretion, turnover, or action.