H
Hana Raslova
Researcher at Université Paris-Saclay
Publications - 103
Citations - 7123
Hana Raslova is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Megakaryocyte & Haematopoiesis. The author has an hindex of 30, co-authored 96 publications receiving 6373 citations. Previous affiliations of Hana Raslova include Institut Gustave Roussy & University of Paris.
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Journal ArticleDOI
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James,Valérie Ugo,Jean-Pierre Le Couedic,Judith Staerk,François Delhommeau,Catherine Lacout,Loïc Garçon,Hana Raslova,Roland Berger,Annelise Bennaceur-Griscelli,Jean-Luc Villeval,Stefan N. Constantinescu,Nicole Casadevall,William Vainchenker +13 more
TL;DR: A clonal and recurrent mutation in the JH2 pseudo-kinase domain of the Janus kinase 2 (JAK2) gene in most (> 80%) polycythaemia vera patients leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity and induces erythrocytosis in a mouse model.
Journal ArticleDOI
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
Maria Castedo,Jean-Luc Perfettini,Thomas Roumier,Alexander Valent,Hana Raslova,Kenichi Yakushijin,David A. Horne,Jean Feunteun,Gilbert M. Lenoir,René H. Medema,William Vainchenker,Guido Kroemer +11 more
TL;DR: A molecular pathway through which DNA damage, failure to arrest the cell cycle and inhibition of apoptosis can favor the occurrence of cytogenetic abnormalities that are likely to participate in oncogenesis is delineated.
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Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
Ilyas Chachoua,Ilyas Chachoua,Christian Pecquet,Christian Pecquet,Mira El-Khoury,Harini Nivarthi,Roxana-Irina Albu,Roxana-Irina Albu,Caroline Marty,Vitalina Gryshkova,Vitalina Gryshkova,Jean-Philippe Defour,Jean-Philippe Defour,Gaëlle Vertenoeil,Gaëlle Vertenoeil,Anna Ngo,Ann Koay,Hana Raslova,Pierre J. Courtoy,Meng Ling Choong,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu,Stefan N. Constantinescu +24 more
TL;DR: This study provides a novel signaling paradigm, whereby a mutated chaperone constitutively activates cytokine receptor signaling, and knocking down either MPL/TpoR or JAK2 in megakaryocytic progenitors from patients carrying CALR mutations inhibited cytokine-independent megakARYocytic colony formation.
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Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
Caroline Marty,Caroline Marty,Caroline Marty,Christian Pecquet,Christian Pecquet,Harini Nivarthi,Mira El-Khoury,Mira El-Khoury,Mira El-Khoury,Ilyas Chachoua,Ilyas Chachoua,Micheline Tulliez,Micheline Tulliez,Micheline Tulliez,Jean-Luc Villeval,Jean-Luc Villeval,Jean-Luc Villeval,Hana Raslova,Hana Raslova,Hana Raslova,Robert Kralovics,Stefan N. Constantinescu,Stefan N. Constantinescu,Isabelle Plo,Isabelle Plo,Isabelle Plo,William Vainchenker,William Vainchenker,William Vainchenker +28 more
TL;DR: It is confirmed in c-mpl- and tpo-deficient mice that expression of Mpl, but not of Tpo, was essential for the CALR mutants to induce thrombocytosis in vivo, although Tpo contributes to disease penetrance.
Journal ArticleDOI
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/ Jacobsen thrombopenia
Hana Raslova,Emiko Komura,Jean Pierre Le Couédic,Frédéric Larbret,Najet Debili,Jean Feunteun,Olivier Danos,Olivier Albagli,William Vainchenker,Rémi Favier +9 more
TL;DR: The role of transient monoallelic expression of a gene essential for differentiation in the genesis of human haploinsufficiency-associated disease is pointed to and such a mechanism may be involved in the pathogenesis of other congenital or acquired genetic diseases.