H
Helen Sheldon
Researcher at University of Oxford
Publications - 33
Citations - 2963
Helen Sheldon is an academic researcher from University of Oxford. The author has contributed to research in topics: Angiogenesis & Gene silencing. The author has an hindex of 19, co-authored 29 publications receiving 2628 citations. Previous affiliations of Helen Sheldon include John Radcliffe Hospital.
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Journal ArticleDOI
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
Carme Camps,Francesca M. Buffa,Stefano Colella,John Moore,Christos Sotiriou,Helen Sheldon,Adrian L. Harris,Jonathan M. Gleadle,Jiannis Ragoussis +8 more
TL;DR: It is shown that hsa-miR-210 overexpression is induced by hypoxia in a HIF-1α– and VHL-dependent fashion and its expression levels in breast cancer samples are an independent prognostic factor.
Journal ArticleDOI
New mechanism for notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
Helen Sheldon,Emily Heikamp,Helen Turley,R Dragovic,Peter H. Thomas,Chern Ein Oon,Russell Leek,Mariola J. Edelmann,Benedikt M. Kessler,Richard C.A. Sainson,Ian L. Sargent,Ji-Liang Li,Adrian L. Harris +12 more
TL;DR: Evidence is presented that Dll4 is incorporated into endothelial exosomes and reversed in phenotype appears to enhance vessel formation and is a new form of signaling for Notch ligands that expands their signaling potential beyond cell-cell contact.
Journal ArticleDOI
microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer
Francesca M. Buffa,Carme Camps,Laura Winchester,Cameron Snell,Harriet E. Gee,Helen Sheldon,Marian Taylor,Adrian L. Harris,Jiannis Ragoussis +8 more
TL;DR: The integrated microRNA-mRNA global profiling approach has identified microRNAs independently associated with prognosis in breast cancer, and has validated known and predicted micro RNA-target interactions, and elucidated their association with key pathways that could represent novel therapeutic targets.
Journal ArticleDOI
The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis.
Harriet E. Gee,Francesca M. Buffa,Carlos Camps,Anassuya Ramachandran,Russell Leek,Marian Taylor,M Patil,Helen Sheldon,Guy N J Betts,Jarrod J Homer,Catharine M L West,Jiannis Ragoussis,Adrian L. Harris +12 more
TL;DR: Small-nucleolar RNAs are important in cancer prognosis, and their use as reference genes can introduce bias in associations between miRNA and pathology or outcome when determining miRNA expression.
Journal ArticleDOI
Recurrent PTPRB and PLCG1 mutations in angiosarcoma
Sam Behjati,Sam Behjati,Patrick S. Tarpey,Helen Sheldon,Inigo Martincorena,Peter Van Loo,Peter Van Loo,Gunes Gundem,David C. Wedge,Manasa Ramakrishna,Susanna L. Cooke,Nischalan Pillay,Nischalan Pillay,Hans Kristian Moen Vollan,Hans Kristian Moen Vollan,Hans Kristian Moen Vollan,Elli Papaemmanuil,Hans Koss,Hans Koss,Tom D. Bunney,Claire Hardy,Olivia Joseph,Sancha Martin,Laura Mudie,Adam Butler,Jon W. Teague,M Patil,Graham Steers,Yu Cao,Curtis Gumbs,Davis R. Ingram,Alexander J. Lazar,Latasha Little,Harshad S. Mahadeshwar,Alexei Protopopov,Ghadah A. Al Sannaa,Sahil Seth,Xingzhi Song,Jiabin Tang,Jianhua Zhang,Vinod Ravi,Keila E. Torres,Bhavisha Khatri,Dina Halai,Ioannis Roxanis,Daniel Baumhoer,Roberto Tirabosco,M Fernanda Amary,Chris Boshoff,Chris Boshoff,Ultan McDermott,Matilda Katan,Michael R. Stratton,P. Andrew Futreal,Adrienne M. Flanagan,Adrienne M. Flanagan,Adrian L. Harris,Adrian L. Harris,Peter J. Campbell,Peter J. Campbell +59 more
TL;DR: This work employed whole-genome, whole-exome and targeted sequencing to study the somatic changes underpinning primary and secondary angiosarcoma, and identified recurrent mutations in two genes, PTPRB and PLCG1, which are intimately linked to angiogenesis.