Herbert Budka

TL;DR: It is demonstrated that HIV-1 infection associates with elevated KYNA synthesis in the brain, and drugs which influence the synthesis of the endogenous neuroprotectant KYNA may become useful in the therapy of neuropsychiatric manifestations of HIV- 1 infected patients.

TL;DR: It is suggested that dysfunction of blood flow regulation due to increased arterial stiffness caused by hypertension-induced intimal fibrosis and loss of medial SMCs is an essential mechanism resulting in diffuse myelin loss of the cerebral white matter in BE, whereas luminal stenosis or occlusion and adventitial fibrosis are secondary.

TL;DR: In this article, the authors compared the immunohistochemical detection of DNA synthesis using antibodies against exogenously injected 5-bromodeoxyuridine (BrdU), which is a tedious procedure and not useful for routine investigations.

TL;DR: It is illustrated that the phenomenon of prion strain adaptation is more common than generally thought and could be observed upon serial transmission without changing the host species.

TL;DR: It is concluded that glioblastoma patients with immunohistochemically detectable p53 protein expression, who received adjuvant radio- and chemotherapy, have a significantly better overall survival, possibly due to increased sensitivity to this adjUvant treatment.