H
Herbert Budka
Researcher at University of Zurich
Publications - 417
Citations - 26786
Herbert Budka is an academic researcher from University of Zurich. The author has contributed to research in topics: Neuropathology & PRNP. The author has an hindex of 85, co-authored 412 publications receiving 25100 citations. Previous affiliations of Herbert Budka include Medical University of Vienna & University of Pécs.
Papers
More filters
Journal ArticleDOI
Complement activation in human prion disease.
Gabor G. Kovacs,Philippe Gasque,Thomas Ströbel,Elisabeth Lindeck-Pozza,Michaela Strohschneider,James W. Ironside,Herbert Budka,Marin Guentchev +7 more
TL;DR: In the diseased human brains, the presence of active compounds of the complement system, like C1q and C3b, in extracellular disease-associated prion protein deposits and the membrane attack complex in neurons is demonstrated.
Journal ArticleDOI
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders
Gabor G. Kovacs,Stefan Klöppel,Ingeborg Fischer,Suzanne Dorner,Elisabeth Lindeck-Pozza,Peter Birner,Ingolf C. Bötefür,Peter Pilz,Benedikt Volk,Herbert Budka +9 more
TL;DR: It is concluded that there is disease- and nucleus-specific alteration of serotonin synthesis in the raphe, which is related to neurodegenerative diseases and Parkinson's disease.
Journal ArticleDOI
Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo
Johannes A. Hainfellner,Till Voigtländer,Thomas Ströbel,Peter R. Mazal,Alessia Maddalena,Adriano Aguzzi,Herbert Budka +6 more
TL;DR: It is concluded that human and murine fibroblasts can express GFAP in vivo, and the somatic distribution of GFAP expressing fibro Blasts indicates origin from the neural crest.
Journal ArticleDOI
Deposition of disease-associated prion protein involves the peripheral nervous system in experimental scrapie
Martin H. Groschup,Michael Beekes,Patricia A. McBride,Michael Hardt,Johannes A. Hainfellner,Herbert Budka +5 more
TL;DR: The need to consider the PNS in natural scrapie and other TSEs including bovine spongiform encephalopathy as potential source of infectivity is considered.
Journal ArticleDOI
Severe depletion of mitochondrial DNA in spinal muscular atrophy.
Alexandra Berger,Johannes A. Mayr,David Meierhofer,Ulrike Fötschl,Reginald E. Bittner,Herbert Budka,Claude Grethen,Michael Huemer,Barbara Kofler,Wolfgang Sperl +9 more
TL;DR: The results indicate that mitochondrial DNA depletion in SMA is a consequence of severe atrophy, and has to be differentiated by measurement of complex II from an isolated reduction of mtDNA as found in patients with mitochondriocytopathies and the so-called mtDNA depletion syndrome.