Herbert Budka

TL;DR: A clear dissociation between GFAP and S100P defines Alzg II as a peculiar glial reaction with a rather selective deficit of GFAP metabolism (“gliofibrillary dystrophy”).

TL;DR: Fructose-5 is identified as a gene involved in Charcot-Marie-Tooth neuropathies and heterozygous fibulin-5 mutations are revealed in 2% of patients with age-related macular degeneration, which adumbrates a new syndrome by linking concurrent pathologic alterations affecting peripheral nerves, eyes and skin to mutations in the fibulin -5 gene.

TL;DR: This study provides compelling evidence that noninfectious amyloids with a structure different from that of PrPSc could lead to transmissible prion disease and has numerous implications for understanding the etiology of prion and other neurodegenerative diseases.

TL;DR: A 24-year-old female presented with a 3-year history of a suprasellar and intraventricular solid midline process measuring about 3×4 cm, which most likely represents a peculiar variant of meningioma with prominent production of GFAP, as previously described.

TL;DR: The presentation of a 25-year-old homosexual AIDS patient with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy suggests that HIV infection of the brain may cause predominant cortical nerve cell loss, and that HIVEncephalopathy is not necessarily due to white matter lesions.