D
Daniel Mead
Researcher at Wellcome Trust Sanger Institute
Publications - 29
Citations - 3457
Daniel Mead is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Population. The author has an hindex of 13, co-authored 27 publications receiving 2729 citations. Previous affiliations of Daniel Mead include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle,Heather Elding,Heather Elding,Tao Jiang,Dave Allen,Dace Ruklisa,Dace Ruklisa,Alice L. Mann,Daniel Mead,Heleen J. Bouman,Fernando Riveros-Mckay,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,John J. Lambourne,John J. Lambourne,Suthesh Sivapalaratnam,Suthesh Sivapalaratnam,Kate Downes,Kate Downes,Kousik Kundu,Kousik Kundu,Lorenzo Bomba,Kim Berentsen,John Bradley,John Bradley,Louise C. Daugherty,Louise C. Daugherty,Olivier Delaneau,Kathleen Freson,Stephen F. Garner,Stephen F. Garner,Luigi Grassi,Luigi Grassi,Jose A. Guerrero,Jose A. Guerrero,Matthias Haimel,Eva M. Janssen-Megens,Anita Kaan,Mihir A Kamat,Bowon Kim,Amit Mandoli,Jonathan Marchini,Jonathan Marchini,Joost H.A. Martens,Stuart Meacham,Stuart Meacham,Karyn Megy,Karyn Megy,Jared O'Connell,Jared O'Connell,Romina Petersen,Romina Petersen,Nilofar Sharifi,S.M. Sheard,James R Staley,Salih Tuna,Martijn van der Ent,Klaudia Walter,Shuang-Yin Wang,Eleanor Wheeler,Steven P. Wilder,Valentina Iotchkova,Valentina Iotchkova,Carmel Moore,Jennifer G. Sambrook,Jennifer G. Sambrook,Hendrik G. Stunnenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Stephen Kaptoge,Stephen Kaptoge,Taco W. Kuijpers,Enrique Carrillo-de-Santa-Pau,David Juan,Daniel Rico,Alfonso Valencia,Lu Chen,Lu Chen,Bing Ge,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yang,Roderic Guigó,Stephan Beck,Dirk S. Paul,Dirk S. Paul,Tomi Pastinen,David Bujold,Guillaume Bourque,Mattia Frontini,Mattia Frontini,Mattia Frontini,John Danesh,David J. Roberts,David J. Roberts,Willem H. Ouwehand,Adam S. Butterworth,Adam S. Butterworth,Adam S. Butterworth,Nicole Soranzo +103 more
TL;DR: A genome-wide association analysis in the UK Biobank and INTERVAL studies is performed, providing evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations betweenBlood cell indices and cardiovascular disease may be non-causal.
Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Lu Chen,Lu Chen,Bing Ge,Francesco Paolo Casale,Louella Vasquez,Tony Kwan,Diego Garrido-Martín,Stephen Watt,Ying Yan,Kousik Kundu,Kousik Kundu,Simone Ecker,Avik Datta,David J. Richardson,Frances Burden,Frances Burden,Daniel Mead,Alice L. Mann,José M. Fernández,Sophia Rowlston,Sophia Rowlston,Steven P. Wilder,Samantha Farrow,Samantha Farrow,Xiaojian Shao,John J. Lambourne,Adriana Redensek,Cornelis A. Albers,Vyacheslav Amstislavskiy,Sofie Ashford,Sofie Ashford,Kim Berentsen,Lorenzo Bomba,Guillaume Bourque,David Bujold,Stephan Busche,Maxime Caron,Shu-Huang Chen,Warren A. Cheung,Oliver Delaneau,Emmanouil T. Dermitzakis,Heather Elding,Irina Colgiu,Frederik Otzen Bagger,Frederik Otzen Bagger,Frederik Otzen Bagger,Paul Flicek,Ehsan Habibi,Valentina Iotchkova,Valentina Iotchkova,Eva M. Janssen-Megens,Bowon Kim,Hans Lehrach,Ernesto Lowy,Amit Mandoli,Filomena Matarese,Matthew T. Maurano,John A. Morris,Vera Pancaldi,Farzin Pourfarzad,Karola Rehnström,Karola Rehnström,Augusto Rendon,Thomas Risch,Nilofar Sharifi,Marie-Michelle Simon,Marc Sultan,Alfonso Valencia,Klaudia Walter,Shuang-Yin Wang,Mattia Frontini,Mattia Frontini,Mattia Frontini,Stylianos E. Antonarakis,Laura Clarke,Marie-Laure Yaspo,Stephan Beck,Roderic Guigó,Daniel Rico,Joost H.A. Martens,Willem H. Ouwehand,Taco W. Kuijpers,Taco W. Kuijpers,Dirk S. Paul,Dirk S. Paul,Hendrik G. Stunnenberg,Oliver Stegle,Kate Downes,Kate Downes,Tomi Pastinen,Nicole Soranzo +90 more
TL;DR: High-resolution genetic, epigenetic, and transcriptomic profiling in three major human immune cell types from up to 197 individuals yields insights into cell-type-specific correlation between diverse genomic inputs, more generalizable correlations between these inputs, and defines molecular events that may underpin complex disease risk.
Journal ArticleDOI
Genomic epidemiology of artemisinin resistant malaria
A. Amato,A. Amato,Olivo Miotto,Olivo Miotto,Olivo Miotto,Charles J. Woodrow,Charles J. Woodrow,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Ipsita Sinha,Susana Campino,Daniel Mead,Eleanor Drury,Mihir Kekre,Mandy Sanders,Alfred Amambua-Ngwa,Chanaki Amaratunga,L. Amenga-Etego,Voahangy Andrianaranjaka,Tobias O. Apinjoh,Elizabeth A. Ashley,Sarah Auburn,Gordon A. Awandare,Vito Baraka,Vito Baraka,Alyssa E. Barry,Alyssa E. Barry,Maciej F. Boni,Steffen Borrmann,Steffen Borrmann,Teun Bousema,OraLee H. Branch,Peter C. Bull,Peter C. Bull,Kesinee Chotivanich,David J. Conway,David J. Conway,Alister Craig,Nicholas P. J. Day,Nicholas P. J. Day,A. Djimdé,Christiane Dolecek,Christiane Dolecek,Arjen M. Dondorp,Arjen M. Dondorp,Chris Drakeley,P. Duffy +46 more
TL;DR: It is shown that African kelch13 mutations have originated locally, and that kelCh13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes.
Journal ArticleDOI
Genetic diversity of the African malaria vector Anopheles gambiae.
Alistair Miles,Alistair Miles,Nicholas J. Harding,Giordano Bottà,Giordano Bottà,Chris S Clarkson,Chris S Clarkson,Tiago Antao,Tiago Antao,Tiago Antao,Krzysztof Kozak,Daniel R. Schrider,Andrew D. Kern,Seth Redmond,Igor V. Sharakhov,Igor V. Sharakhov,Richard D. Pearson,Richard D. Pearson,Christina M. Bergey,Michael C. Fontaine,Martin J. Donnelly,Martin J. Donnelly,Mara K. N. Lawniczak,Diego Ayala,Nora J. Besansky,Austin Burt,Beniamino Caputo,Alessandra della Torre,H. Charles J. Godfray,Matthew W. Hahn,Janet Midega,Daniel E. Neafsey,Samantha M. O’Loughlin,João Pinto,Michelle M. Riehle,Kenneth D. Vernick,David Weetman,Craig S. Wilding,Craig S. Wilding,Bradley J. White,Arlete D. Troco,Abdoulaye Diabaté,Carlo Costantini,Kyanne R. Rohatgi,Nohal Elissa,Boubacar Coulibaly,Joao Dinis,Charles M. Mbogo,Philip Bejon,Henry D. Mawejje,Jim Stalker,Kirk A. Rockett,Eleanor Drury,Daniel Mead,Anna E. Jeffreys,Christina Hubbart,Kate Rowlands,Alison T. Isaacs,Dushyanth Jyothi,Cinzia Malangone,Paul Vauterin,Ben Jeffery,Ian J. Wright,Lee Hart,Krzysztof Kluczynski,Victoria Cornelius,Bronwyn MacInnis,Christa Henrichs,Rachel Giacomantonio,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +70 more
TL;DR: These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size.