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Igor Smirnov
Researcher at University of Virginia
Publications - 55
Citations - 7993
Igor Smirnov is an academic researcher from University of Virginia. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 23, co-authored 39 publications receiving 5202 citations. Previous affiliations of Igor Smirnov include State University of New York Upstate Medical University & Weizmann Institute of Science.
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Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
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Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Sandro Da Mesquita,Antoine Louveau,Andrea Vaccari,Igor Smirnov,R. Chase Cornelison,Kathryn M. Kingsmore,Christian Contarino,Christian Contarino,Suna Onengut-Gumuscu,Emily Farber,Daniel M.S. Raper,Daniel M.S. Raper,Kenneth E. Viar,Romie D. Powell,Wendy Baker,Nisha Dabhi,Robin Bai,Rui Cao,Song Hu,Stephen S. Rich,Jennifer M. Munson,Jennifer M. Munson,M. Beatriz S. Lopes,Christopher C. Overall,Scott T. Acton,Jonathan Kipnis +25 more
TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.
Journal ArticleDOI
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Antoine Louveau,Jasmin Herz,Maria Nordheim Alme,Andrea Francesca Salvador,Michael Q. Dong,Kenneth E. Viar,S. Grace Herod,James Knopp,Joshua C. Setliff,Alexander L. Lupi,Sandro Da Mesquita,Elizabeth L. Frost,Alban Gaultier,Tajie H. Harris,Rui Cao,Song Hu,John R. Lukens,Igor Smirnov,Christopher C. Overall,Guillermo Oliver,Jonathan Kipnis +20 more
TL;DR: It is demonstrated that meningeal lymphatics drain CSF-derived macromolecules and immune cells and play a key role in regulating neuroinflammation and may represent a new therapeutic target for multiple sclerosis.
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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Anthony J. Filiano,Yang Xu,Nicholas J. Tustison,Rachel Marsh,Wendy Baker,Igor Smirnov,Christopher C. Overall,Sachin P. Gadani,Stephen D. Turner,Zhiping Weng,Sayeda Najamussahar Peerzade,Hao Chen,Kevin S. Lee,Michael Scott,Mark P. Beenhakker,Vladimir Litvak,Jonathan Kipnis +16 more
TL;DR: It is shown that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions, and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
Journal ArticleDOI
Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
James C. Cronk,Anthony J. Filiano,Antoine Louveau,Ioana Marin,Rachel Marsh,Emily Ji,Dylan H. Goldman,Igor Smirnov,Nicholas S. Geraci,Scott T. Acton,Christopher C. Overall,Jonathan Kipnis +11 more
TL;DR: It is demonstrated that therapeutic engraftment of brain-engrafting macrophages may be possible with irradiation-free conditioning regimens and that beM&phgr;s maintain a unique functional and transcriptional identity as compared with microglia.