Karolina Pierzynowska

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: An update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging is provided, highlighting that mitochondrial ROS may be a decisive target in clinical practice.

TL;DR: It is found that high genistein dose (150 mg/kg/day; the dose significantly higher than those used previously in AD studies by others) can activate autophagy in the streptozotocin‐induced rat model of the sporadic form of AD, and it is concluded thatAutophagy‐dependent mechanism is responsible for genisteIn‐mediated correction of AD when this isoflavone is used at the high dose.

TL;DR: Different ways by which autophagy can be stimulated can be considered as a therapeutic strategy in metabolic neurodegenerative diseases, and these aspects are reviewed and discussed in this article.

TL;DR: Although no therapy is available for Sanfilippo disease now, recent years did bring important breakthroughs in this aspect, and clinical trials are being conducted with enzyme replacement therapy, gene therapy, and substrate reduction therapy.